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Tiny Eye Cell ‘Twitch’ Could Transform Early Blindness Detection
An NTU Singapore-led team has, for the first time, captured a tiny mechanical twitch in the eye’s night-vision cells as they detect light. The breakthrough could pave the way for earlier, non-invasive detection of diseases that cause blindness.
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Gene Therapy ‘Off Switch’ Aims to Ease Pain Without Addiction
Researchers at the University of Pennsylvania and collaborators have engineered a brain-targeted gene therapy that dials down pain in mice without activating reward pathways linked to addiction. The work could lay the groundwork for non-addictive treatments for chronic pain.
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How a Tumor-Suppressing Protein Could Boost Head and Neck Cancer Immunity
Researchers at MD Anderson have identified a tumor-suppressing protein that is shut down by excess glutamine in head and neck cancers, blunting the immune response. Blocking glutamine metabolism restored immune activity in preclinical models, pointing to a new way to help resistant tumors respond to treatment.
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Breast Cancer Drug Shows Promise Against Deadly Leukemia
Oregon Health & Science University researchers have identified a drug duo that could help people with acute myeloid leukemia overcome treatment resistance. By pairing a standard leukemia drug with a breast cancer medicine, the team saw stronger, longer-lasting anti-cancer effects in lab and animal studies.
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‘Molecular Glue’ Drug Strategy Targets Resistant Lung Cancer
University of Michigan researchers have found a way to use a “molecular glue” to stabilize a tumor-suppressing protein and shrink drug-resistant lung tumors in mice. The approach could help extend the effectiveness of existing treatments for KRAS-mutant cancers.
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Experimental Drug NU-9 Blocks Early Alzheimer’s Damage in Mice
An experimental Northwestern drug, NU-9, stopped early brain inflammation and toxic protein buildup in an Alzheimer’s mouse model. The work points to a future where people at risk might start treatment long before memory loss begins.
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MIT mRNA Breakthrough Hints at Rejuvenating Aging Immune Systems
MIT and Broad Institute researchers used mRNA to turn the liver into a temporary immune-support “factory” in aging mice. The approach restored T cell strength, improved vaccine responses and made cancer immunotherapy work better.
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New ‘Plug-and-Play’ Immunotherapy May Boost Cancer Treatment
MIT and Stanford researchers have engineered a new class of “plug-and-play” immunotherapy molecules that help immune cells recognize and attack tumors. The approach could extend the benefits of cancer immunotherapy to many more patients.
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New Nanoparticle Strategy Boosts Precision of mRNA Cancer Vaccines
Binghamton University researchers have designed tumor-seeking mRNA nanoparticles that use COVID-era immune memory to help the body recognize and destroy cancer cells. The approach could make future cancer vaccines more precise and easier on patients than chemotherapy or radiation.
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MSU Builds First Human Heart Organoid to Model Atrial Fibrillation
Michigan State University researchers have built the first human heart organoid that faithfully mimics atrial fibrillation. The tiny, beating models could speed up safer drug development and pave the way for personalized heart treatments.
