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Scientists Pinpoint Enzyme That Fuels Treatment-Resistant Cancers
UC San Diego researchers have identified an enzyme that shatters chromosomes in cancer cells, driving rapid evolution and drug resistance. The finding opens a new path to potentially slow or stop some of the most aggressive tumors.
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Nighttime Brain Stimulation Helps Preserve Fading Memories in Mice
By boosting specific brain waves during sleep, Cornell scientists helped mice hold on to memories that would normally fade within hours. The work could guide new approaches to treating Alzheimer’s disease and other forms of dementia.
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Blocking Collagen Signaling May Help Drugs Reach Pancreatic Tumors
A team in Japan has found a way to weaken the dense scar-like tissue that blocks drugs from reaching pancreatic tumors. By targeting collagen signaling, they boosted the movement of antibody and nanomedicine therapies through a 3D cancer model.
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Zebrafish Breakthrough Could Speed Up Norovirus Vaccines
Norovirus sickens millions and kills hundreds of thousands each year, yet vaccine development has lagged. A new zebrafish-based genetic system from Osaka researchers could finally change that.
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Brain Circuit Discovery May Point to New Way to Prevent Opioid Relapse
Washington State University researchers have pinpointed a brain circuit that appears to drive opioid relapse and found ways to quiet it in rats, sharply reducing heroin-seeking behavior. The work could lay the groundwork for future brain-based treatments to help people get through the most intense periods of craving.
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Blood Tests for Cancer Detection: A Step Closer to Reality, Say Scientists
Imagine detecting cancer through a simple blood or urine test instead of invasive biopsies. This vision is becoming increasingly realistic, thanks to breakthrough research on exosomes — tiny particles released by cells carrying molecular signatures of cancer. Scientists from the University of Sharjah, led by Mohammad Harb Semreen, a professor of pharmaceutical chemistry, have highlighted the…
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Researchers Discover Shared Genetic Roots for Behavior in Golden Retrievers and Humans
A pioneering study led by researchers at the University of Cambridge has uncovered compelling genetic links between golden retrievers and humans, reshaping our understanding of how certain behaviors and emotional traits manifest in both species. The research, published in the journal Proceedings of the National Academy of Sciences, is a significant first. It demonstrates that…
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Gene Scissors in ‘Stealth Mode’ Help to Advance Cancer Research
In a groundbreaking development, researchers at ETH Zurich have unveiled a pioneering method that significantly enhances the precision of CRISPR/Cas9 technology in cancer research. Their findings, published in the journal Cell, employs a molecular “cloak of invisibility” that allows CRISPR/Cas9 components to evade detection by the immune system in mouse models, thereby providing more accurate…
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New Sensor Enables Real-Time Observation of DNA Repair
Researchers at Utrecht University in the Netherlands have developed an innovative fluorescent sensor that allows scientists to observe DNA repair processes in real time within living cells. This groundbreaking technology, published in the journal Nature Communications, holds the potential to significantly advance cancer research, drug safety testing and studies of aging. Ordinarily, DNA within cells…
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Researchers Develop New Antibodies That Inhibit Inflammation in Autoimmune Diseases
An international team of researchers led by UMC Utrecht has announced a breakthrough in the fight against autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and immune thrombocytopenia (ITP). The team has developed and characterized two first-in-class antibodies, C01 and C04, which specifically block the high-affinity IgG receptor FcγRI, also known as…
