{"id":9152,"date":"2024-10-30T21:35:21","date_gmt":"2024-10-30T21:35:21","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=9152"},"modified":"2024-10-30T21:35:22","modified_gmt":"2024-10-30T21:35:22","slug":"groundbreaking-study-shows-fasting-mimicking-diet-can-support-kidney-function","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/groundbreaking-study-shows-fasting-mimicking-diet-can-support-kidney-function\/","title":{"rendered":"Groundbreaking Study Shows Fasting-Mimicking Diet Can Support Kidney Function"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A new study has identified a low-salt, fasting-mimicking diet that significantly improves kidney function in both animal models and human patients with chronic kidney disease. <\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a groundbreaking study, researchers from Children&#8217;s Hospital Los Angeles, in collaboration with the USC Longevity Institute of the Davis School of Gerontology and international partners, have discovered a promising dietary intervention that might revolutionize the treatment of chronic kidney disease (CKD). The study, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adl5514\" title=\"\">published<\/a> in Science Translational Medicine, reveals that a low-salt, fasting-mimicking diet (LS-FMD) can significantly improve kidney function and slow disease progression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chronic kidney disease involves the irreversible loss of podocytes, critical cells in the kidney&#8217;s glomerular filtration barrier. This deterioration leads to end-stage kidney disease for which there is currently no effective prevention strategy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Led by Laura Perin, co-director of the GOFARR Laboratory at The Saban Research Institute, and Valter Longo, professor at the USC Longevity Institute of the Davis School of Gerontology, the research team conducted experiments on animal models with CKD. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">They administered six cycles of LS-FMD, reflecting the dietary recommendations for CKD patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Promising Results in Animal Models<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The results were astonishing. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The specialized diet not only slowed the deterioration of kidney structures but also induced the reprogramming of podocytes, effectively restoring the kidney\u2019s filtration system. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The treated rodents exhibited significant reductions in key markers of kidney damage, such as the albumin-to-creatinine ratio (ACR) and blood urea nitrogen (BUN), compared to rodents on a regular diet.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWhen we examined these animal models, we found that long-term kidney function and structure was improved,&#8221; Perin said in a <a href=\"https:\/\/www.chla.org\/blog\/experts\/research-and-breakthroughs\/fasting-mimicking-diet-restores-kidney-function-study\" title=\"\">news release<\/a>. &#8220;The transcriptional profile of the major kidney structures resembled those of a healthy rat. We saw evidence on the molecular and cellular level that this fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pilot Study Shows Human Benefits<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Translating this success to humans, a pilot study involving 13 CKD patients showed that the LS-FMD diet was kidney-protective, reducing proteinuria and improving endothelial function. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The observed changes in gene expression suggest that the diet&#8217;s benefits in rodents may extend to human patients, offering a new potential intervention for managing kidney disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThese results show that FMD cycles can promote reprogramming\/regeneration in mice and rats but also increase circulating progenitor cells in humans, so they should be tested further for treatment of progressive kidney diseases,\u201d Longo said in the news release. \u201cThis fasting-mimicking diet seems to induce changes in gene expression that slow kidney degradation, suggesting potential interventions for patients with chronic kidney disease.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Significance and Future Implications<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This research highlights the significant potential of dietary interventions in treating chronic kidney disease, a condition that affects millions worldwide and currently has limited treatment options. The study&#8217;s findings suggest that controlled dietary modifications could preserve kidney function and delay disease progression, offering hope for patients battling this debilitating condition.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As the next step, the researchers advocate for larger, comprehensive clinical trials to confirm these results and explore the feasibility of LS-FMD as a standard therapeutic approach for CKD.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By illuminating the link between diet and kidney health, this study paves the way for innovative, non-invasive treatment strategies, promising renewed vitality and improved quality of life for those with chronic kidney conditions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a groundbreaking study, researchers from Children&#8217;s Hospital Los Angeles, in collaboration with the USC Longevity Institute of the Davis School of Gerontology and international partners, have discovered a promising dietary intervention that might revolutionize the treatment of chronic kidney disease (CKD). The study, published in Science Translational Medicine, reveals that a low-salt, fasting-mimicking diet [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-9152","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a groundbreaking study, researchers from Children&#8217;s Hospital Los Angeles, in collaboration with the USC Longevity Institute of the Davis School of Gerontology and international partners, have discovered a promising dietary intervention that might revolutionize the treatment of chronic kidney disease (CKD). The study, published in Science Translational Medicine, reveals that a low-salt, fasting-mimicking diet&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/9152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=9152"}],"version-history":[{"count":6,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/9152\/revisions"}],"predecessor-version":[{"id":9208,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/9152\/revisions\/9208"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=9152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=9152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=9152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}