{"id":8142,"date":"2024-10-23T14:52:53","date_gmt":"2024-10-23T14:52:53","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=8142"},"modified":"2024-10-23T14:52:54","modified_gmt":"2024-10-23T14:52:54","slug":"study-reveals-physical-tests-key-in-treating-metastatic-lung-cancer","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/study-reveals-physical-tests-key-in-treating-metastatic-lung-cancer\/","title":{"rendered":"Study Reveals Physical Tests Key in Treating Metastatic Lung Cancer"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Simple physical tests like standing and walking can help manage treatment for metastatic lung cancer, a pivotal study reveals. Researchers identified potential biomarkers, offering hope for improved prognosis and individualized therapy plans.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A new study from researchers in Brazil and the United States has uncovered that simple physical tests such as sitting down, standing up and walking can significantly aid physicians in managing treatments for metastatic lung cancer patients. This pivotal research, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.14288\" title=\"\">published<\/a> in the European Journal of Clinical Investigation, suggests that physical performance could play a crucial role in prognosis and personalized therapy plans.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study was led by researchers at the University of S\u00e3o Paulo\u2019s Medical School (FM-USP) in Brazil and Harvard Medical School, with funding from S\u00e3o Paulo Research Foundation (FAPESP). The findings indicate that two blood plasma substances, serine and M22G, could become biomarkers to predict chemotherapy responses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cachexia Anorexia Syndrome and Physical Performance<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Willian das Neves Silva, the study&#8217;s first author who carried out the study for his doctoral research, explains that cachexia anorexia syndrome \u2014 a condition marked by the severe loss of skeletal muscle mass \u2014 is prevalent in advanced-stage cancer. This syndrome typically leads to symptoms like fatigue, muscle weakness and significant weight loss.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In cases of non-small cell lung cancer (NSCLC), the most common form of lung cancer, the study highlighted that muscle mass alone was insufficient for prognostic assessments. Instead, muscle function proved to be a more crucial factor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe saw that function is more important. Not just having muscles, but what the patient can do with them. The study showed that physical fitness matters more than muscle mass. Most patients were debilitated and suffering from some degree of cachexia [pronounced loss of weight and muscle mass]. Patients with better physical performance live longer, and this has nothing to do with their overall condition,\u201d Silva said in a <a href=\"https:\/\/agencia.fapesp.br\/performance-in-physical-tests-can-help-manage-treatment-for-metastatic-lung-cancer\/53097\" title=\"\">news release<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Implications for Treatment and Future Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The results of the study suggest that oncologists might better manage chemotherapy regimens and make informed referrals to palliative care or complementary therapies based on patients&#8217; physical test performances. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gilberto de Castro Junior, a professor at FM-USP who served as one of Silva&#8217;s thesis advisors, emphasized the connection between physical test outcomes and oxygen consumption.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe showed that patients who performed poorly in the simple physical tests also displayed impaired oxygen consumption, whereas patients who performed well were satisfactory in this item,\u201d Castro Junior said in the news release. &#8220;We believe the inflammatory process associated with the tumor results in a set of metabolites circulating in the bloodstream with potentially negative effects on muscle cell metabolism.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Study Sample and Methodology<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The research involved 55 NSCLC patients treated at the S\u00e3o Paulo State Cancer Institute (ICESP), most of whom were long-term smokers. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The patients underwent various physical tests and submitted blood samples for analysis. Notably, physical performance, rather than muscle mass, was a better indicator of endurance during chemotherapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cAt Harvard, the blood samples and muscle cells collected in Brazil were submitted to metabolomic analysis to detect the intermediate or end-products of their metabolism in an attempt to identify molecules that could be used as markers of the disease,\u201d Silva added.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Future Goals<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The research team aims to further investigate the potential of these biomarkers and improve understanding of how physical exercise could complement cancer treatments. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recent findings by the same research team, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rco2.106\" title=\"\">published<\/a> in JCSM Communications, shed light on inflammation, food aversion and intramuscular fat as additional predictors of prognosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe know patients with poor muscle function survive less. Could we somehow reverse this process by improving muscle function through exercise? This is what we aim to find out now,\u201d Castro Junior added.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study from researchers in Brazil and the United States has uncovered that simple physical tests such as sitting down, standing up and walking can significantly aid physicians in managing treatments for metastatic lung cancer patients. This pivotal research, published in the European Journal of Clinical Investigation, suggests that physical performance could play a [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-8142","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A new study from researchers in Brazil and the United States has uncovered that simple physical tests such as sitting down, standing up and walking can significantly aid physicians in managing treatments for metastatic lung cancer patients. This pivotal research, published in the European Journal of Clinical Investigation, suggests that physical performance could play a&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/8142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=8142"}],"version-history":[{"count":7,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/8142\/revisions"}],"predecessor-version":[{"id":8252,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/8142\/revisions\/8252"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=8142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=8142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=8142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}