{"id":4236,"date":"2024-08-22T21:29:56","date_gmt":"2024-08-22T21:29:56","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=4236"},"modified":"2024-10-16T21:21:14","modified_gmt":"2024-10-16T21:21:14","slug":"breakthrough-discovery-in-fatty-liver-disease-offers-new-hope-for-patients","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/breakthrough-discovery-in-fatty-liver-disease-offers-new-hope-for-patients\/","title":{"rendered":"Breakthrough Discovery in Fatty Liver Disease Offers New Hope for Patients"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Scientists have uncovered how certain white blood cell subpopulations influence the progression of metabolic dysfunction-associated steatohepatitis (MASH), offering a potential pathway for new treatments.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a landmark study <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2405746121\" title=\"\">published<\/a> in the Proceedings of the National Academy of Sciences (PNAS), researchers have identified specific macrophage subpopulations that critically impact the progression and regression of metabolic dysfunction-associated steatohepatitis (MASH). The breakthrough offers a glimmer of hope for millions affected by this prevalent liver disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Formerly known as nonalcoholic steatohepatitis (NASH), MASH is an inflammatory liver disease characterized by scarring or fibrosis, progressively impairing liver function. It is a major precursor to cirrhosis and liver cancer and currently stands as the second leading cause of liver transplants in the United States, surpassed only by cirrhosis due to chronic hepatitis C infection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study, led by scientists from Sanford Burnham Prebys and the University of California San Diego School of Medicine, investigated the dynamic interactions between liver cells and macrophages, a type of white blood cell. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;In MASH, Kupffer cells (a type of macrophage that resides in the liver) are lost and replaced by four distinct macrophage subpopulations,&#8221; David Brenner, co-corresponding author and president and CEO of Sanford Burnham Prebys, said in a <a href=\"https:\/\/sbpdiscovery.org\/press\/macrophage-mix-helps-determine-rate-and-fate-of-fatty-liver-disease\/\" title=\"\">news release<\/a>. &#8220;When the disease is in regression, &#8230; two lipid associated macrophage subpopulations are dominant and express TREM2, a cell receptor that regulates cell survival, proliferation and anti-inflammatory responses.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Senior author Debanjan Dhar, an associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys, emphasized the significance of these findings. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Our findings suggest that lipid-associated macrophages that express TREM2 and TREM2 are required both for the emergence of more liquid associated macrophages and for their reparative functions,&#8221; he said in the news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This implies that the presence of TREM2+ macrophages is instrumental in restricting and even reversing the progression of MASH and fibrosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The discovery could pave the way for new therapeutic approaches. The researchers speculate that a TREM2 agonist, a drug that mimics TREM2 functions, might become a valuable asset in treating MASH\/fibrosis, especially when combined with lifestyle changes. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;There is only one approved treatment for MASH, and it was only approved earlier this year,&#8221; added co-corresponding author Christopher Glass, a professor of cellular and molecular medicine at UC San Diego. &#8220;Any opportunities to expand clinical options that benefit patients need to be thoroughly pursued because liver disease in this country \u2014 and around the world \u2014 is only getting worse.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MASH often goes undetected due to a lack of early symptoms, contributing to its widespread prevalence. According to the American Liver Foundation, an estimated 80 to 100 million Americans have fatty liver disease, with a significant portion progressing to MASH, cirrhosis or liver cancer if left untreated.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As liver disease continues to escalate globally, the insights from this study could mark an essential step toward developing effective treatments to improve patient outcomes and quality of life.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a landmark study published in the Proceedings of the National Academy of Sciences (PNAS), researchers have identified specific macrophage subpopulations that critically impact the progression and regression of metabolic dysfunction-associated steatohepatitis (MASH). The breakthrough offers a glimmer of hope for millions affected by this prevalent liver disease. Formerly known as nonalcoholic steatohepatitis (NASH), MASH [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-4236","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a landmark study published in the Proceedings of the National Academy of Sciences (PNAS), researchers have identified specific macrophage subpopulations that critically impact the progression and regression of metabolic dysfunction-associated steatohepatitis (MASH). The breakthrough offers a glimmer of hope for millions affected by this prevalent liver disease. Formerly known as nonalcoholic steatohepatitis (NASH), MASH&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/4236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=4236"}],"version-history":[{"count":7,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/4236\/revisions"}],"predecessor-version":[{"id":4455,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/4236\/revisions\/4455"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=4236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=4236"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=4236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}