{"id":3915,"date":"2024-08-20T20:56:12","date_gmt":"2024-08-20T20:56:12","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=3915"},"modified":"2024-10-17T19:00:11","modified_gmt":"2024-10-17T19:00:11","slug":"rosemary-extract-compound-found-to-reduce-cocaine-sensitivity-study-reveals","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/rosemary-extract-compound-found-to-reduce-cocaine-sensitivity-study-reveals\/","title":{"rendered":"Rosemary Extract Compound Found to Reduce Cocaine Sensitivity, Study Reveals"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">In a groundbreaking study led by UC Irvine, researchers reveal that a compound in rosemary extract can decrease cocaine sensitivity by moderating brain activity. This discovery could pave the way for new addiction treatments.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A recent groundbreaking study led by the University of California, Irvine has identified that a specific compound found in rosemary extract, known as carnosic acid, can lower the voluntary intake of cocaine by moderating the brain\u2019s reward response system. This discovery could herald a new era of treatments for addiction.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Published online in the journal Neuron, the <a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(24)00540-3\" title=\"\">study<\/a> focused on a critical brain region called the globus pallidus externus (GPe). This area acts as a regulator for how the brain reacts to cocaine. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers found that within the GPe, parvalbumin-positive neurons are pivotal in managing the brain&#8217;s response to the drug by affecting the activity of neurons that release dopamine, the chemical associated with pleasure.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThere are currently no effective therapeutics for dependence on psychostimulants such as cocaine, which, along with opioids, represent a substantial health burden,\u201d Kevin Beier, associate professor of physiology and biophysics at UC Irvine and corresponding author of the study, said in a <a href=\"https:\/\/news.uci.edu\/2024\/08\/20\/uc-irvine-led-team-finds-that-compound-in-rosemary-extract-can-reduce-cocaine-sensitivity\/\" title=\"\">news release<\/a>. \u201cOur study deepens our understanding of the basic brain mechanisms that increase vulnerability to substance use disorder-related outcomes and provides a foundation for the development of new interventions.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Through experiments conducted on mice, the team discovered that exposure to cocaine made the parvalbumin-positive cells in the GPe more excitable, resulting in decreased levels of certain proteins critical for regulating cell activity. They found that carnosic acid, the active compound in rosemary extract, specifically binds to these affected channels, offering a promising method to mitigate the brain&#8217;s response to cocaine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOnly a subset of individuals are vulnerable to developing a substance use disorder, but we cannot yet identify who they are. If globus pallidus cell activity can effectively predict response to cocaine, it could be used to measure likely responses and thus serve as a biomarker for the most vulnerable,\u201d added Beier. \u201cFurthermore, it\u2019s possible that carnosic acid could be given to those at high risk to reduce the response to cocaine.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The implications of this research are vast. Finding a natural compound like carnosic acid, which can control the response to addictive substances, opens new avenues for addiction therapies that are both effective and have lower potential for side effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The next phase of research will delve into assessing any negative side effects of carnosic acid, as well as determining the optimal dosage and timing for its administration. The researchers are also keen to explore its potential in curbing dependencies on other drugs and in developing more potent and targeted variants of the compound.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to the team from UC Irvine, scientists from the University of West Virginia and the University of Colorado collaborated on the study. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent groundbreaking study led by the University of California, Irvine has identified that a specific compound found in rosemary extract, known as carnosic acid, can lower the voluntary intake of cocaine by moderating the brain\u2019s reward response system. This discovery could herald a new era of treatments for addiction. Published online in the journal [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-3915","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A recent groundbreaking study led by the University of California, Irvine has identified that a specific compound found in rosemary extract, known as carnosic acid, can lower the voluntary intake of cocaine by moderating the brain\u2019s reward response system. This discovery could herald a new era of treatments for addiction. Published online in the journal&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=3915"}],"version-history":[{"count":9,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3915\/revisions"}],"predecessor-version":[{"id":3939,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3915\/revisions\/3939"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=3915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=3915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=3915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}