{"id":37879,"date":"2026-05-29T11:27:00","date_gmt":"2026-05-29T11:27:00","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=37879"},"modified":"2026-05-29T13:15:35","modified_gmt":"2026-05-29T13:15:35","slug":"new-antibiotic-design-method-could-defeat-drug-resistant-bacteria","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-antibiotic-design-method-could-defeat-drug-resistant-bacteria\/","title":{"rendered":"New Antibiotic Design Method Could Defeat Drug-Resistant Bacteria"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A research team led by King&#8217;s College London has unveiled a chemical redesign strategy that keeps antibiotics working inside bacterial cells, even against drug-resistant strains. The approach could breathe new life into existing antibiotics that bacteria have already learned to overcome.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers have developed a novel antibiotic design framework that could change how scientists tackle one of medicine&#8217;s most urgent challenges: drug-resistant bacterial infections. The study, led by King&#8217;s College London and <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.6c00060\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the <em>Journal of Medicinal Chemistry<\/em>, introduces a strategy called &#8220;Efflux Resistance Breaker,&#8221; or ERB, which rewires the chemical structure of antibiotics so bacteria can no longer expel them before they work.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Bacteria Dodge Antibiotics \u2014 and How ERB Fights Back<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most common ways bacteria develop resistance is through molecular pumps embedded in their cell walls, known as efflux pumps. These pumps act like bouncers, ejecting antibiotic molecules before the drug can accumulate to a lethal concentration inside the cell. The result is a bacterium that survives treatment it should not be able to withstand.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The ERB method tackles this by chemically restructuring antibiotic molecules themselves, making them harder for efflux pumps to recognize and remove. Once inside a bacterial cell, the redesigned antibiotic lingers at higher concentrations \u2014 long enough to do its job and kill the bacteria.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Senior author Khondaker Miraz Rahman, a professor of medicinal chemistry at King&#8217;s College London, emphasized both the urgency and the promise of this work:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">&#8220;Antimicrobial resistance is rising, but the number of truly new antibiotics in development remains worryingly low. Our work shows that we can redesign antibiotics so they stay inside bacterial cells at higher concentrations and overcome resistance mechanisms that would normally make them ineffective,&#8221; Rahman said in a news release. &#8220;This approach could help us design better new antibiotics, but it could also help revive existing antibiotic classes that bacteria have learned to defeat.&#8221; <\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">A Built-In Defense, Not a Patch<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">What separates the ERB approach from earlier strategies is that resistance-breaking capability is woven directly into the antibiotic molecule itself \u2014 not added as a separate companion drug. Previous efforts often paired antibiotics with standalone efflux pump inhibitors, a two-drug combination that introduces its own set of complications. With ERB, the antibiotic is essentially designed to protect itself from ejection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Co-author J. Mark Sutton of the UK Health Security Agency, a key collaborator on the project, described the significance of the chemical design approach:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">&#8220;Efflux pumps are a major cause of antibiotic resistance because they reduce the concentration of drug inside the bacterial cell. This study shows that rational chemical design can be used to overcome that problem. By building efflux resistance directly into the antibiotic, we may be able to restore activity against bacteria that are no longer controlled by current drugs,&#8221; Sutton said in the news release.<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">The study serves as a proof of concept, demonstrating that sustaining high concentrations of antibiotic within bacterial cells can overcome resistance \u2014 including in strains that have already developed reduced sensitivity to current medications.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why It Matters for Students and Young Adults<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Antimicrobial resistance is not a distant or abstract problem. College campuses, dormitories, gyms and clinics are environments where bacterial infections spread easily \u2014 and where drug-resistant strains like MRSA have long posed real threats to students. As more bacteria evolve defenses against the antibiotics doctors rely on, infections that were once straightforward to treat can become dangerous or even life-threatening.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The World Health Organization has flagged antimicrobial resistance as one of the top global public health threats, estimating that drug-resistant infections already cause hundreds of thousands of deaths each year. Without new or revitalized treatments, that toll is expected to rise sharply in coming decades \u2014 making breakthroughs like ERB especially significant for the generation that will live with those consequences.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Comes Next<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The team is now working to commercialize the ERB platform and move antibiotics developed under this framework toward clinical trials. The goal is to translate the laboratory findings into treatments patients can actually use against drug-resistant infections.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Beyond developing new drugs, the researchers believe ERB could serve as a broad strategy for reviving older antibiotic classes that have lost their edge \u2014 potentially expanding the arsenal available to doctors without requiring the full cost and timeline of discovering an entirely new drug class from scratch.<\/p>\n\n\n\n<div style=\"height:9px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/www.kcl.ac.uk\/news\/new-antibiotic-design-could-help-treat-drug-resistant-infections\" target=\"_blank\" rel=\"noopener\" title=\"\">King&#8217;s College London<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team at King&#8217;s College London has unveiled a chemical redesign strategy that keeps antibiotics working inside bacterial cells, even against drug-resistant strains. The approach could breathe new life into existing antibiotics that bacteria have already learned to overcome.<\/p>\n","protected":false},"author":3,"featured_media":37878,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[12],"tags":[2513,2515,2514,1737,50,2516,2517],"class_list":["post-37879","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-antibiotic-resistance","tag-antimicrobial-resistance","tag-drug-resistant-bacteria","tag-infectious-disease","tag-kings-college-london","tag-medicinal-chemistry","tag-uk-health-security-agency"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"A research team at King&#039;s College London has unveiled a chemical redesign strategy that keeps antibiotics working inside bacterial cells, even against drug-resistant strains. 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