{"id":34892,"date":"2026-03-04T17:06:00","date_gmt":"2026-03-04T17:06:00","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=34892"},"modified":"2026-03-05T20:07:23","modified_gmt":"2026-03-05T20:07:23","slug":"uc-irvine-chemists-reveal-early-spark-behind-age-related-cataracts","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/uc-irvine-chemists-reveal-early-spark-behind-age-related-cataracts\/","title":{"rendered":"UC Irvine Chemists Reveal Early Spark Behind Age-Related Cataracts"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">UC Irvine chemists have pinpointed how a tiny chemical tweak in a long-lived eye protein can nudge it toward clumping, offering fresh clues to how age-related cataracts begin and how they might one day be prevented without surgery.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Cataracts, a leading cause of blindness worldwide, may start with a surprisingly subtle change in the eye\u2019s lens, according to new research from the University of California, Irvine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a study <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667074726000042\" title=\"\">published<\/a> in <em>Biophysical Reports<\/em>, UC Irvine chemists show that a tiny chemical modification in a single lens protein can make it more likely to clump together over time. Those clumps can eventually cloud the lens and blur vision, pointing to a possible first step in the development of age-related cataracts.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The work focuses on crystallins, a family of proteins that act like microscopic glass bricks in the lens. Packed in high concentrations and arranged with remarkable precision, crystallins help keep the lens clear and flexible so it can focus light onto the retina.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Unlike many other tissues, the eye\u2019s lens does not regularly replace its proteins. The crystallins you are born with are meant to last your entire life. That durability comes with a downside: decades of exposure to ultraviolet light and other environmental stresses can gradually damage these proteins, even if they still appear mostly intact.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lead author Yeonseong (Catherine) Seo, a doctoral candidate in chemistry at UC Irvine, noted the team was struck by how little it took to tip a stable protein toward trouble.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWhat surprised us is that the protein can still look mostly normal, but even a small chemical change makes it much more likely to stick to other proteins,\u201d Seo said in a new release. \u201cOver time, those small interactions can add up and cloud the lens.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study zeroed in on age-related cataracts, the most common form of the disease. Unlike cataracts caused by inherited mutations or injury, age-related cataracts typically develop slowly as everyday exposures, especially ultraviolet light from the sun, create oxidative stress in the eye. That stress can subtly alter amino acids, the building blocks of proteins, changing how they behave.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To understand those changes at a molecular level, the UC Irvine team used a powerful technique called genetic code expansion, or GCE. This method allows scientists to build proteins that contain specific, nonstandard chemical groups at precise positions, essentially \u201cediting\u201d a protein one atom at a time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cGCE lets us make very precise changes to a protein,\u201d Seo added. \u201cWe used it to copy one kind of damage that shows up in age-related cataracts and see exactly what it does.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers applied GCE to a lens protein called \u03b3S-crystallin, introducing a small oxidative modification at one particular site that is known to be altered in aging lenses. Even after this change, the protein remained folded and appeared stable under normal conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The real difference emerged when the protein was stressed. When the team heated the modified \u03b3S-crystallin, it clumped together much more readily than the unmodified version. That behavior mirrors what happens in cataracts, where damaged proteins aggregate and scatter light.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe protein doesn\u2019t fall apart right away,\u201d added Seo. \u201cIt just becomes a little more likely to interact with its neighbors, and over time that can lead to clumping.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To dig deeper, the researchers are now examining how oxidation affects the natural motions of crystallin proteins. Proteins are not rigid; they constantly flex and shift, and those subtle movements help keep vulnerable regions tucked safely inside. If oxidation changes how a protein moves, it may briefly expose sticky patches that encourage aggregation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe\u2019re essentially watching how the protein breathes,\u201d Seo added. \u201cIf certain parts start moving more than they should, it can briefly open up areas that are normally protected.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By linking age-related chemical damage to changes in protein motion and stickiness, the team hopes to map out how the lens\u2019s defenses gradually erode over a lifetime. That kind of molecular roadmap could eventually guide new strategies to slow or prevent cataracts before they interfere with vision.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Today, cataracts are treated almost entirely with surgery, in which the cloudy lens is removed and replaced with an artificial one. The procedure is common and generally safe, but it requires specialized care and is not equally accessible worldwide. As populations age, the number of people needing cataract surgery is expected to rise sharply, putting pressure on health systems and leaving many patients in low-resource settings without treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Corresponding author Rachel Martin, a UC Irvine professor of chemistry, emphasized just how universal the problem is.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cAlmost everyone who lives long enough will get age-related cataracts,\u201d Martin said in the news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That makes it especially important to understand the disease at its roots. Martin noted the precision of genetic code expansion gives researchers a new way to do that.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cGCE enables us to study specific changes that happen with proteins in the aging lens, furthering our understanding of what causes cataracts at the molecular level. Understanding the loss of function that comes with aging could lead to non-surgical treatments or improved artificial lenses in the future,\u201d she added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While such treatments are still on the horizon, the UC Irvine study marks a key step: showing that a single, realistic oxidative change can quietly prime a long-lived lens protein for trouble years down the line.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As Seo and her colleagues continue to probe how aging reshapes the lens at the molecular level, their findings add to a growing body of research that views cataracts not as an inevitable, mysterious clouding, but as a gradual, understandable process. By catching the earliest sparks of protein damage, scientists hope to one day keep the lens clear for longer, preserving sight well into old age.<\/p>\n\n\n\n<div style=\"height:11px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/news.uci.edu\/2026\/03\/04\/uc-irvine-chemists-shed-light-on-how-age-related-cataracts-may-begin\/\" target=\"_blank\" rel=\"noopener\" title=\"\">University of California, Irvine<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>UC Irvine chemists have pinpointed how a tiny chemical tweak in a long-lived eye protein can nudge it toward clumping, offering fresh clues to how age-related cataracts begin and how they might one day be prevented without surgery.<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[173],"class_list":["post-34892","post","type-post","status-publish","format-standard","hentry","category-health","tag-uc-irvine"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"UC Irvine chemists have pinpointed how a tiny chemical tweak in a long-lived eye protein can nudge it toward clumping, offering fresh clues to how age-related cataracts begin and how they might one day be prevented without surgery.","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/34892","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=34892"}],"version-history":[{"count":5,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/34892\/revisions"}],"predecessor-version":[{"id":34919,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/34892\/revisions\/34919"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=34892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=34892"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=34892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}