{"id":3214,"date":"2024-08-06T21:37:45","date_gmt":"2024-08-06T21:37:45","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=3214"},"modified":"2024-10-16T21:25:12","modified_gmt":"2024-10-16T21:25:12","slug":"groundbreaking-study-on-alzheimers-reveals-genetic-mutations-impact-on-brain","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/groundbreaking-study-on-alzheimers-reveals-genetic-mutations-impact-on-brain\/","title":{"rendered":"Groundbreaking Study on Alzheimer\u2019s Reveals Genetic Mutation\u2019s Impact on Brain"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Researchers led by UC Irvine have made a significant discovery in understanding the TREM2 R47H genetic mutation\u2019s effect on Alzheimer\u2019s disease, which could pave the way for groundbreaking early interventions and therapies.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a pioneering study that could reshape the future of Alzheimer\u2019s treatment, a research team led by the University of California, Irvine has unveiled how the TREM2 R47H genetic mutation drives the development of beta-amyloid plaques, crucial in the progression of late-onset Alzheimer\u2019s disease. Utilizing advanced single-cell Merfish spatial transcriptomics technology, this investigation provides unprecedented insights into the mutation\u2019s effects at the cellular level.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Published in the journal Molecular Psychiatry, the <a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02651-0\" title=\"\">study<\/a> offers a detailed comparison between normal mice and genetically altered mouse models mirroring human Alzheimer&#8217;s conditions. The discovery highlighted how the TREM2 mutation disrupted beta-amyloid plaque accumulation patterns in various brain regions responsible for memory, reasoning and speech. It further showed distinct impacts on cell types and their gene expressions in the vicinity of these plaques.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cAlzheimer\u2019s disease progresses differently in individuals with various genetic risk factors,\u201d Xiangmin Xu, a professor of anatomy and neurobiology at UC Irvine and the study&#8217;s principal investigator, said in a <a href=\"https:\/\/news.uci.edu\/2024\/08\/06\/uc-irvine-led-team-reveals-how-trem2-genetic-mutation-affects-late-onset-alzheimers\/\" title=\"\">news release<\/a>. \u201cBy profiling known mutations, we can develop early, personalized treatments before cognitive decline begins.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team meticulously analyzed 19 sections of mouse brains and over 400,000 cells using the Merfish technique. This cutting-edge analysis allowed them to observe gene expression patterns and their regulation, significantly advancing the understanding of cellular functions and reactions to stimuli in Alzheimer\u2019s disease. The TREM2 R47H mutation, in particular, led to changes in how microglia and astrocyte cells responded to inflammation and how neurons communicated, revealing critical pathways involved in disease progression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cEarly intervention is key to preventing severe cognitive decline,\u201d Xu added. \u201cThis is the first study to look at the entire brain at such a detailed level, enabling us to gain a deeper understanding of how the TREM2 R47H mutation impacts gene expression in specific cell types. These insights can help develop targeted therapies that address these changes and can lead to early intervention strategies that help prevent or slow down the progression of Alzheimer\u2019s disease.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research was spearheaded by postdoctoral scholar Kevin G. Johnston and associate researcher Zhiqun Tan from UC Irvine\u2019s Department of Anatomy and Neurobiology. Contributing members included experts from UC Irvine\u2019s Department of Neurobiology and Behavior, Department of Developmental and Cell Biology and Department of Statistics, along with collaborators from UC San Diego.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study\u2019s implications are profound, offering a new avenue for therapeutic strategies. By identifying the specific genetic and cellular changes caused by the TREM2 mutation, the research paves the way for personalized medicine approaches that could significantly improve outcomes for Alzheimer&#8217;s patients. The work, funded by various National Institutes of Health grants, represents a beacon of hope in the battle against this devastating disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a pioneering study that could reshape the future of Alzheimer\u2019s treatment, a research team led by the University of California, Irvine has unveiled how the TREM2 R47H genetic mutation drives the development of beta-amyloid plaques, crucial in the progression of late-onset Alzheimer\u2019s disease. Utilizing advanced single-cell Merfish spatial transcriptomics technology, this investigation provides unprecedented [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-3214","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a pioneering study that could reshape the future of Alzheimer\u2019s treatment, a research team led by the University of California, Irvine has unveiled how the TREM2 R47H genetic mutation drives the development of beta-amyloid plaques, crucial in the progression of late-onset Alzheimer\u2019s disease. Utilizing advanced single-cell Merfish spatial transcriptomics technology, this investigation provides unprecedented&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=3214"}],"version-history":[{"count":2,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3214\/revisions"}],"predecessor-version":[{"id":3228,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3214\/revisions\/3228"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=3214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=3214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=3214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}