{"id":31781,"date":"2025-11-24T15:27:50","date_gmt":"2025-11-24T15:27:50","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=31781"},"modified":"2025-11-24T15:27:51","modified_gmt":"2025-11-24T15:27:51","slug":"gene-scissors-in-stealth-mode-help-to-advance-cancer-research","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/gene-scissors-in-stealth-mode-help-to-advance-cancer-research\/","title":{"rendered":"Gene Scissors in &#8216;Stealth Mode&#8217; Help to Advance Cancer Research"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Scientists at ETH Zurich have created a groundbreaking method for using CRISPR\/Cas9 in cancer research without triggering immune responses, paving the way for more precise discoveries and effective treatments.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a groundbreaking development, researchers at ETH Zurich have unveiled a pioneering method that significantly enhances the precision of CRISPR\/Cas9 technology in cancer research. Their findings, <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425011365\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the journal Cell, employs a molecular &#8220;cloak of invisibility&#8221; that allows CRISPR\/Cas9 components to evade detection by the immune system in mouse models, thereby providing more accurate data for developing cancer therapies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CRISPR\/Cas9 technology has revolutionized genetic research, enabling scientists to swiftly edit genes. This has made it invaluable in identifying genetic factors that influence cancer development and metastasis. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, because CRISPR\/Cas9 components are primarily derived from bacteria, they are often recognized as foreign by the immune systems of mice, leading to a distorted response that can skew experimental results.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research, spearheaded by Nicola Aceto, a professor of molecular oncology at ETH Zurich, has rigorously demonstrated this problem for the first time. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;We were surprised at how significantly this can distort the results of CRISPR screens,&#8221; first author Massimo Saini, an ETH Pioneer Fellow in Aceto&#8217;s group, said in a news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To counter this, the team devised a strategy to make CRISPR\/Cas9 &#8220;invisible&#8221; to the immune system. This was achieved by temporarily exposing tumor cells to the CRISPR\/Cas9 components and then isolating only those cells in which a gene had been successfully silenced. These modified cells no longer contained elements that could provoke an immune response.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Additionally, the team replaced traditional reporter genes with a new gene closely resembling a naturally produced protein in mice, ensuring it would go undetected by the immune system. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;We have developed a method for performing CRISPR screens in mice with intact immune systems, without incurring any undesirable side effects,&#8221; added Aceto. &#8220;This is as close to cancer patients as you can get.&#8221; <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The innovative method holds particular promise for humanized mice \u2014 models that possess a human immune system \u2014 which makes the findings highly relevant for human cancer therapies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;With this system, we are now achieving a new level of accuracy and \u2013 particularly significant for us \u2013 we are able to discover new targets for therapies,&#8221; Saini added.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research team has already achieved a major breakthrough using this cloaked CRISPR system. By targeting the genes AMH and AMHR2 in a breast cancer mouse model, they observed a significant reduction in metastasis formation. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Clinically, high levels of AMH protein in tumors correlate with more frequent relapses and higher mortality rates, indicating that these genes play a critical role in cancer progression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;The significance of this signalling pathway has been underestimated,&#8221; added Aceto. &#8220;Thanks to CRISPR in stealth mode, we are now able to uncover connections that were previously hidden.&#8221;<\/p>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/ethz.ch\/en\/news-and-events\/eth-news\/news\/2025\/11\/gene-scissors-in-camouflage-mode-help-in-the-search-for-cancer-therapies.html\" target=\"_blank\" rel=\"noopener\" title=\"\">ETH Zurich<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a groundbreaking development, researchers at ETH Zurich have unveiled a pioneering method that significantly enhances the precision of CRISPR\/Cas9 technology in cancer research. Their findings, published in the journal Cell, employs a molecular &#8220;cloak of invisibility&#8221; that allows CRISPR\/Cas9 components to evade detection by the immune system in mouse models, thereby providing more accurate [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[88],"class_list":["post-31781","post","type-post","status-publish","format-standard","hentry","category-science","tag-eth-zurich"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a groundbreaking development, researchers at ETH Zurich have unveiled a pioneering method that significantly enhances the precision of CRISPR\/Cas9 technology in cancer research. Their findings, published in the journal Cell, employs a molecular &#8220;cloak of invisibility&#8221; that allows CRISPR\/Cas9 components to evade detection by the immune system in mouse models, thereby providing more accurate&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=31781"}],"version-history":[{"count":9,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31781\/revisions"}],"predecessor-version":[{"id":31817,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31781\/revisions\/31817"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=31781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=31781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=31781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}