{"id":31765,"date":"2025-11-24T14:32:14","date_gmt":"2025-11-24T14:32:14","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=31765"},"modified":"2025-11-24T14:32:15","modified_gmt":"2025-11-24T14:32:15","slug":"new-study-reveals-most-genetic-high-cholesterol-cases-go-undiagnosed","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-study-reveals-most-genetic-high-cholesterol-cases-go-undiagnosed\/","title":{"rendered":"New Study Reveals Most Genetic High Cholesterol Cases Go Undiagnosed"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A new Mayo Clinic study reveals that nearly 90% of individuals with a genetic condition causing high cholesterol go undiagnosed, calling for routine genetic screening to prevent early heart disease.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A new study from the Mayo Clinic has uncovered a glaring gap in genetic screening guidelines, potentially jeopardizing the heart health of countless individuals. The research found that nearly 90% of people with familial hypercholesterolemia, a genetic condition leading to extremely high cholesterol levels and early heart disease, remain undiagnosed under current national protocols.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Familial hypercholesterolemia, one of the most common genetic disorders, affects an estimated 1 in 200 to 250 people globally, leading to elevated levels of low-density lipoprotein (LDL) cholesterol \u2014 widely known as &#8220;bad&#8221; cholesterol \u2014 from birth. Left undetected and untreated, these individuals are at a significantly higher risk for heart attacks and strokes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lead author Niloy Jewel Samadder, a Mayo Clinic gastroenterologist and cancer geneticist, emphasized the urgency of their findings.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Our findings expose a blind spot in current national guidelines, which rely on cholesterol levels and family history to determine who should receive genetic testing,&#8221; Samadder said in a news release. &#8220;If we can find those at risk of cardiovascular disease early, we can treat it early and change its course and likely save lives.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cardiovascular disease remains the leading cause of death among adults in the United States, affecting millions annually. High cholesterol is a major risk factor. Yet, most individuals with familial hypercholesterolemia are not flagged by standard genetic testing criteria, underscoring the urgency for revised screening methods.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study, <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCGEN.125.005174\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the journal Circulation Genomic and Precision Medicine, analyzed exome sequencing data \u2014 reading the protein-coding regions of the genome where most disease-causing variants reside. Conducted through the <a href=\"https:\/\/newsnetwork.mayoclinic.org\/discussion\/mayo-clinics-largest-ever-exome-study-offers-blueprint-for-biomedical-breakthroughs\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tapestry DNA research study<\/a>, part of Mayo Clinic\u2019s visionary plan to integrate genomics into routine patient care, the research included over 84,000 participants from Mayo Clinic sites in Arizona, Florida and Minnesota.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research identified 419 individuals carrying genetic variants known to cause familial hypercholesterolemia. Alarmingly, nearly 75% of these individuals would not have been candidates for genetic testing based solely on their cholesterol levels or family history.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Samadder and his team advocate for integrating genetic screening into routine preventive care. This approach could identify high-risk patients much earlier, enabling timely intervention and potentially saving lives. <\/p>\n\n\n\n<div style=\"height:11px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/newsnetwork.mayoclinic.org\/discussion\/most-people-with-a-genetic-condition-that-causes-significantly-high-cholesterol-go-undiagnosed-mayo-clinic-study-finds\/\" target=\"_blank\" rel=\"noopener\" title=\"\">Mayo Clinic<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study from the Mayo Clinic has uncovered a glaring gap in genetic screening guidelines, potentially jeopardizing the heart health of countless individuals. The research found that nearly 90% of people with familial hypercholesterolemia, a genetic condition leading to extremely high cholesterol levels and early heart disease, remain undiagnosed under current national protocols. Familial [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[110],"class_list":["post-31765","post","type-post","status-publish","format-standard","hentry","category-health","tag-mayo-clinic"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A new study from the Mayo Clinic has uncovered a glaring gap in genetic screening guidelines, potentially jeopardizing the heart health of countless individuals. The research found that nearly 90% of people with familial hypercholesterolemia, a genetic condition leading to extremely high cholesterol levels and early heart disease, remain undiagnosed under current national protocols. Familial&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=31765"}],"version-history":[{"count":8,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31765\/revisions"}],"predecessor-version":[{"id":31779,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31765\/revisions\/31779"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=31765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=31765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=31765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}