{"id":3176,"date":"2024-08-06T18:48:28","date_gmt":"2024-08-06T18:48:28","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=3176"},"modified":"2024-10-17T14:15:00","modified_gmt":"2024-10-17T14:15:00","slug":"johns-hopkins-researchers-discover-molecular-cause-of-covid-19-diarrhea-paving-way-for-potential-treatments","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/johns-hopkins-researchers-discover-molecular-cause-of-covid-19-diarrhea-paving-way-for-potential-treatments\/","title":{"rendered":"Johns Hopkins Researchers Discover Molecular Cause of COVID-19 Diarrhea, Paving Way for Potential Treatments"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Johns Hopkins Medicine scientists have identified key molecular mechanisms driving COVID-19-related diarrhea using innovative &#8220;mini intestine&#8221; models. This breakthrough offers a pathway to potential treatments and enhances our understanding of long COVID-19.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers at Johns Hopkins Medicine have made significant strides in understanding the molecular underpinnings of COVID-19-related diarrhea, offering hope for new treatments and insights into long COVID-19. Using advanced models that simulate human intestines, the team has uncovered several mechanisms causing this debilitating symptom.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The<a href=\"https:\/\/www.cmghjournal.org\/article\/S2352-345X(24)00138-3\/fulltext\" title=\"\"> study<\/a>, published in Cellular and Molecular Gastroenterology and Hepatology, utilized enteroids, miniature versions of human intestines grown from stem cells. These \u201cmini intestine-in-a-dish\u201d models helped the team observe how SARS-CoV-2, the virus responsible for COVID-19, alters protein function in gut cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWhile COVID-19 diarrhea is not life-threatening like cholera, it can often predict a severe case and also who gets the long covid syndrome,\u201d Mark Donowitz, Emeritus Professor of Medicine and Physiology at Johns Hopkins University School of Medicine, said in a <a href=\"https:\/\/www.hopkinsmedicine.org\/news\/newsroom\/news-releases\/2024\/08\/johns-hopkins-medicine-scientists-probe-molecular-cause-of-covid-19-related-diarrhea-revealing-potential-treatments\" title=\"\">news release<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers found that COVID-19-related diarrhea shares some commonalities with other diarrheal illnesses, involving disrupted sodium and chloride absorption and increased chloride secretion. Notably, the team identified that calcium-activated chloride channels, rather than proteins associated with cystic fibrosis, were driving the chloride secretion in this instance.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">An unusual discovery was that COVID-19 diarrhea results from a combination of direct effects on transport proteins and inflammation \u2014 a dual mechanism not commonly observed in other diarrheas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team hypothesizes that the inflammatory response in COVID-19 diarrhea may mirror the inflammation seen in the lungs and other organs affected by the virus, suggesting that anti-inflammatory treatments could be beneficial.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe precise mechanisms of long COVID are a big mystery, although we now know that the virus can persist in the intestine for a long time,\u201d added Donowitz. \u201cThe next big question is to determine what exactly allows the virus to live in the intestine and what allows the virus to live over a long period of time.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This groundbreaking research, backed by the Johns Hopkins University School of Medicine and the National Institutes of Health, also holds promise for addressing long COVID-19, a condition affecting a significant number of those who recover from the virus.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study&#8217;s co-authors include a collaborative team from Johns Hopkins Medicine, the Johns Hopkins Bloomberg School of Public Health and the University of New Mexico Health Sciences Center, among others. Their collective work provides not only a deeper understanding of a pressing COVID-19 symptom but also a foundation for future therapeutic strategies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Johns Hopkins Medicine have made significant strides in understanding the molecular underpinnings of COVID-19-related diarrhea, offering hope for new treatments and insights into long COVID-19. Using advanced models that simulate human intestines, the team has uncovered several mechanisms causing this debilitating symptom. The study, published in Cellular and Molecular Gastroenterology and Hepatology, utilized [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-3176","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers at Johns Hopkins Medicine have made significant strides in understanding the molecular underpinnings of COVID-19-related diarrhea, offering hope for new treatments and insights into long COVID-19. Using advanced models that simulate human intestines, the team has uncovered several mechanisms causing this debilitating symptom. The study, published in Cellular and Molecular Gastroenterology and Hepatology, utilized&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=3176"}],"version-history":[{"count":3,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3176\/revisions"}],"predecessor-version":[{"id":3211,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3176\/revisions\/3211"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=3176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=3176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=3176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}