{"id":31511,"date":"2025-11-18T19:56:00","date_gmt":"2025-11-18T19:56:00","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=31511"},"modified":"2025-11-18T19:56:01","modified_gmt":"2025-11-18T19:56:01","slug":"new-chemical-compound-shows-promise-in-treating-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-chemical-compound-shows-promise-in-treating-alzheimers-disease\/","title":{"rendered":"New Chemical Compound Shows Promise in Treating Alzheimer\u2019s Disease"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A team of Brazilian researchers at UFABC, supported by FAPESP, has developed a new compound showing promise in treating Alzheimer&#8217;s disease by targeting and degrading harmful beta-amyloid plaques.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-0dfbf163 wp-block-group-is-layout-flex\"><div style=\"font-size:16px;\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p>A team of researchers at the Federal University of ABC (UFABC) in Brazil has made a significant breakthrough in the fight against Alzheimer&#8217;s disease. Supported by the S\u00e3o Paulo Research Foundation (FAPESP), the team has developed a new chemical compound that could offer a new avenue for treatment by degrading the beta-amyloid plaques that are a hallmark of the disease.<\/p>\n\n\n\n<p>Utilizing a multi-faceted approach combining computer simulations, cell culture tests and animal experiments, the researchers found that the compound effectively minimizes memory loss, spatial awareness difficulties and learning issues in rats with induced Alzheimer&#8217;s. <\/p>\n\n\n\n<p>Moreover, the compound, acting as a copper chelator, binds to excess copper in beta-amyloid plaques, facilitating their degradation.<\/p>\n\n\n\n<p>\u201cAbout a decade ago, international studies began to point to the influence of copper ions as an aggregator of beta-amyloid plaques. It was discovered that genetic mutations and changes in enzymes that act in the transport of copper in cells could lead to the accumulation of the element in the brain, favoring the aggregation of these plaques. Thus, the regulation of copper homeostasis [<em>balance<\/em>] has become one of the focuses for the treatment of Alzheimer\u2019s,\u201d Giselle Cerchiaro, a professor in UFABC&#8217;s Center for Natural and Human Sciences who coordinated the study, said in a news release.\u00a0<\/p>\n\n\n\n<p>The team&#8217;s findings, <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschemneuro.5c00291\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the journal ACS Chemical Neuroscience, revealed that the new compound is not only effective but also easy to synthesize. <\/p>\n\n\n\n<p>The compound reduced neuroinflammation, oxidative stress and restored copper balance in the hippocampus \u2014 the brain region responsible for memory. Importantly, the compound demonstrated safety, showing no toxicity to hippocampal cell cultures or in the treated animals.<\/p>\n\n\n\n<p>This research marks a promising development in Alzheimer&#8217;s treatment, especially in the context of the current therapeutic landscape, which largely focuses on symptom relief rather than root causes. With an estimated 50 million people worldwide living with Alzheimer\u2019s disease, new treatments that target the disease&#8217;s fundamental mechanisms are urgently needed.<\/p>\n\n\n\n<p>The researchers are pushing forward with plans to translate these promising preclinical findings into human clinical trials. <\/p>\n\n\n\n<p>\u201cIt\u2019s an extremely simple, safe, and effective molecule. The compound we\u2019ve developed is much less expensive than available drugs. Therefore, even if it only works for part of the population, since Alzheimer\u2019s disease has multiple causes, it\u2019d represent a huge advance over current options,\u201d Cerchiaro added. \u00a0<\/p>\n\n\n\n<p>The UFABC research team&#8217;s development has already led to a patent application, and they are currently seeking partnerships with pharmaceutical companies to further test and potentially commercialize the compound.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Source: <\/strong><a href=\"https:\/\/agencia.fapesp.br\/researchers-develop-chemical-compound-with-potential-against-alzheimers-disease\/56422\" target=\"_blank\" rel=\"noopener\" title=\"\">S\u00e3o Paulo Research Foundation<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of researchers at the Federal University of ABC (UFABC) in Brazil has made a significant breakthrough in the fight against Alzheimer&#8217;s disease. Supported by the S\u00e3o Paulo Research Foundation (FAPESP), the team has developed a new chemical compound that could offer a new avenue for treatment by degrading the beta-amyloid plaques that are [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[503,502],"class_list":["post-31511","post","type-post","status-publish","format-standard","hentry","category-science","tag-fapesp","tag-federal-university-of-abc"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A team of researchers at the Federal University of ABC (UFABC) in Brazil has made a significant breakthrough in the fight against Alzheimer&#8217;s disease. Supported by the S\u00e3o Paulo Research Foundation (FAPESP), the team has developed a new chemical compound that could offer a new avenue for treatment by degrading the beta-amyloid plaques that are&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=31511"}],"version-history":[{"count":8,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31511\/revisions"}],"predecessor-version":[{"id":31600,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31511\/revisions\/31600"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=31511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=31511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=31511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}