{"id":31246,"date":"2025-11-03T17:15:26","date_gmt":"2025-11-03T17:15:26","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=31246"},"modified":"2025-11-03T17:15:28","modified_gmt":"2025-11-03T17:15:28","slug":"new-model-highlights-the-importance-of-early-diabetes-treatment","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-model-highlights-the-importance-of-early-diabetes-treatment\/","title":{"rendered":"New Model Highlights the Importance of Early Diabetes Treatment"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A patient\u2019s simple question led to the creation of DOMUS, a model revealing how early diabetes treatment can significantly impact long-term health outcomes. This breakthrough has powerful implications for patients, clinicians and policymakers.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-0dfbf163 wp-block-group-is-layout-flex\"><div style=\"font-size:16px;\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p>A question from an experienced nurse, living with slightly elevated blood sugars for three years, sparked nearly a decade of intensive research that has now resulted in a revolutionary model poised to transform diabetes care in the United States.<\/p>\n\n\n\n<p>Neda Laiteerapong, a professor of medicine and chief of general internal medicine at the University of Chicago, faced a dilemma when the patient, who had not started treatment, asked, \u201cDid I harm myself by waiting?\u201d<\/p>\n\n\n\n<p>\u201cI wanted to say, \u2018Yes, absolutely,\u2019 but I didn\u2019t have any evidence to support that,\u201d Laiteerapong said in a news release. <\/p>\n\n\n\n<p>This question ignited a pursuit to quantify the costs and benefits of early diabetes treatment.<\/p>\n\n\n\n<p>Laiteerapong, using patient data from Kaiser Permanente, unveiled the Multiethnic Type 2 Diabetes Outcomes Model for the U.S. (DOMUS). <\/p>\n\n\n\n<p><a href=\"https:\/\/diabetesjournals.org\/care\/article\/48\/11\/1942\/163509\/Development-and-Internal-Validation-of-the\" target=\"_blank\" rel=\"noopener\" title=\"\">Published<\/a> in Diabetes Care, DOMUS can predict 14 complications over 15 years and track changes in weight, cholesterol, A1C levels, among other risk factors. Notably, it includes traditional complications such as heart attacks and kidney failure, and also newer concerns such as depression and dementia.<\/p>\n\n\n\n<p>Compared to other models like the UKPDS, which is based on 30 years of data from around 5,000 UK patients, DOMUS utilizes data from a more diverse U.S. cohort \u2014 129,000 patients across 12 years. <\/p>\n\n\n\n<p>\u201cWe wanted to build a model that represented the people we actually treat in the US \u2014 a socioeconomically and racially diverse population,\u201d Laiteerapong added.<\/p>\n\n\n\n<p>The findings confirm the importance of early diabetes treatment. <\/p>\n\n\n\n<p>\u201cFirst-year A1C did, in fact, help predict long-term complications. So yes, those early months matter,\u201d added Laiteerapong.<\/p>\n\n\n\n<p>This insight challenges the &#8220;wait and see&#8221; approach often taken by patients and health care providers in the early stages of diabetes. Even modest delays in treatment can have profound, lasting effects.<\/p>\n\n\n\n<p>Beyond patient care, DOMUS could reshape public health strategies. <\/p>\n\n\n\n<p>\u201cHistorically, when we ask policy questions about diabetes, we often can&#8217;t do it using real people in real time,\u201d Laiteerapong added. \u201cWe have to estimate or simulate the outcomes using mathematical models. These models help us figure out the likelihood of something leading to a potential health outcome and whether an intervention is worth funding.\u201d<\/p>\n\n\n\n<p>The team is now working on external validation and exploring racial and ethnic disparities in outcomes, in addition to the long-term benefits of early A1C control.<\/p>\n\n\n\n<p>\u201cDOMUS can be used by insurers, policymakers, and public health agencies to guide decisions \u2014 especially when clinical trials take too long or aren\u2019t feasible,\u201d concluded Laiteerapong, indicating the vast potential for future collaborations and applications.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Source: <\/strong><a href=\"https:\/\/biologicalsciences.uchicago.edu\/news\/new-model-shows-how-treating-diabetes-early-makes-difference\" target=\"_blank\" rel=\"noopener\" title=\"\">The University of Chicago Division of the Biological Sciences<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A question from an experienced nurse, living with slightly elevated blood sugars for three years, sparked nearly a decade of intensive research that has now resulted in a revolutionary model poised to transform diabetes care in the United States. Neda Laiteerapong, a professor of medicine and chief of general internal medicine at the University of [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[352],"class_list":["post-31246","post","type-post","status-publish","format-standard","hentry","category-health","tag-university-of-chicago"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A question from an experienced nurse, living with slightly elevated blood sugars for three years, sparked nearly a decade of intensive research that has now resulted in a revolutionary model poised to transform diabetes care in the United States. Neda Laiteerapong, a professor of medicine and chief of general internal medicine at the University of&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=31246"}],"version-history":[{"count":7,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31246\/revisions"}],"predecessor-version":[{"id":31264,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/31246\/revisions\/31264"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=31246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=31246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=31246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}