{"id":3074,"date":"2024-08-01T15:28:58","date_gmt":"2024-08-01T15:28:58","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=3074"},"modified":"2024-10-16T21:26:43","modified_gmt":"2024-10-16T21:26:43","slug":"tum-researchers-unveil-breakthrough-technique-to-identify-new-drug-effects","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/tum-researchers-unveil-breakthrough-technique-to-identify-new-drug-effects\/","title":{"rendered":"TUM Researchers Unveil Breakthrough Technique to Identify New Drug Effects"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">In a ground-breaking study, scientists at the Technical University of Munich have mapped the interactions between 144 active substances and around 8,000 proteins, revealing previously unknown effects of existing drugs. This advancement in precision medicine could lead to more individualized and effective treatments for patients.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers at the Technical University of Munich (TUM) have achieved a pivotal breakthrough in precision medicine. They have successfully mapped the interactions of 144 active substances with approximately 8,000 proteins, potentially unlocking unknown therapeutic benefits of existing medications. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This pioneering study, driven by advanced proteomics and the innovative decryptE method, could pave the way for more personalized and effective treatments across various medical fields.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At the heart of this research is Bernhard K\u00fcster, professor of proteomics and bioanalytics at TUM, who leads a dedicated team investigating the molecular mechanisms behind therapeutic drugs and their applications in cancer treatment. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Using mass spectrometry, a technology that rapidly generates and evaluates data, the team meticulously analyzed cell reactions to a range of drug doses over an 18-hour period. This extensive study resulted in the creation of over 1 million dose-response curves, which illustrate the intricate mechanisms of drug effects during treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research findings, now <a href=\"https:\/\/www.nature.com\/articles\/s41587-024-02218-y\" title=\"\">published<\/a> in Nature Biotechnology, have been incorporated into the ProteomicsDB database, making them accessible to the global scientific community. Such comprehensive data can provide critical insights into cancer treatment, emphasizing the importance of understanding molecular-level interactions for determining suitable therapies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One significant discovery from the study was the potential immune system weakening caused by HDAC inhibitors, a class of drugs often used in cancer treatment. This insight was made possible by the capabilities of the decryptE method, which records all cellular interactions of active substances, generating voluminous data sets that researchers can analyze from multiple angles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cMany drugs can do more than we think,\u201d K\u00fcster said in a <a href=\"https:\/\/www.tum.de\/en\/news-and-events\/all-news\/press-releases\/details\/finding-unknown-effects-of-existing-drugs\" title=\"\">news release<\/a>. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">He draws a parallel to Aspirin, originally known for pain relief but later found to thin blood and prevent strokes and heart attacks. K\u00fcster believes that current widely-used drugs may also harbor unknown effects waiting to be discovered systematically through research rather than by chance.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This research represents a leap forward in precision medicine. By identifying how drugs interact with proteins, scientists can tailor treatments to individual patients, reducing side effects and improving the efficacy of therapies. Cancer, with its varied molecular behaviors, is a prime area where such detailed understanding can significantly influence treatment outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The breakthroughs achieved by K\u00fcster and his team highlight the potential of existing medications and the importance of comprehensive molecular analysis. The research community widely anticipates that such advancements will open new avenues for drug repurposing and the discovery of novel therapeutic applications, ultimately transforming patient care and treatment strategies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the Technical University of Munich (TUM) have achieved a pivotal breakthrough in precision medicine. They have successfully mapped the interactions of 144 active substances with approximately 8,000 proteins, potentially unlocking unknown therapeutic benefits of existing medications. This pioneering study, driven by advanced proteomics and the innovative decryptE method, could pave the way for [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-3074","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers at the Technical University of Munich (TUM) have achieved a pivotal breakthrough in precision medicine. They have successfully mapped the interactions of 144 active substances with approximately 8,000 proteins, potentially unlocking unknown therapeutic benefits of existing medications. This pioneering study, driven by advanced proteomics and the innovative decryptE method, could pave the way for&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=3074"}],"version-history":[{"count":7,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3074\/revisions"}],"predecessor-version":[{"id":3117,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/3074\/revisions\/3117"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=3074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=3074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=3074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}