{"id":30722,"date":"2025-10-16T18:53:19","date_gmt":"2025-10-16T18:53:19","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=30722"},"modified":"2025-10-16T18:53:21","modified_gmt":"2025-10-16T18:53:21","slug":"new-study-reveals-potential-key-to-reversing-cellular-aging-in-immune-system","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-study-reveals-potential-key-to-reversing-cellular-aging-in-immune-system\/","title":{"rendered":"New Study Reveals Potential Key to Reversing Cellular Aging in Immune System"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Researchers at the University of Illinois Chicago have identified a protein that could reverse cellular aging in the immune system, showing promise for future treatment of age-related disorders.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers at the University of Illinois Chicago have made a groundbreaking discovery that could revolutionize how we understand and treat age-related disorders in the immune system. The study, <a href=\"https:\/\/ashpublications.org\/blood\/article-abstract\/doi\/10.1182\/blood.2024027432\/547160\/Platelet-Factor-4-PF4-Regulates-Hematopoietic-Stem\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the journal Blood, reveals that a protein called platelet factor 4, which diminishes with age, plays a crucial role in the aging process of blood and immune cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers focused on hematopoietic stem cells. These blood stem cells reside in the bone marrow and are responsible for generating both myeloid cells \u2014 vital for immune response and oxygen transportation \u2014 and lymphoid cells, which fight infections.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As we age, these stem cells gradually shift toward primarily producing myeloid cells, resulting in a weakened immune system. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Our hematopoietic stem cells are very rare,&#8221; Sandra Pinho, an associate professor of pharmacology and regenerative medicine in the College of Medicine, said in a news release. &#8220;We call them the Holy Grail of the immune system.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers discovered that platelet factor 4 serves as a crucial messenger in young bodies, regulating the proliferation of hematopoietic stem cells. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;When stem cells start to divide more often than they should, and if their proliferation is not regulated, they can accumulate mutations over time,&#8221; Pinho added. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In humans, these mutations can lead to inflammation, a higher risk of blood cancers, and cardiovascular disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In their experiments with mice and human bone marrow samples, the team found that replenishing platelet factor 4 in older subjects rejuvenated their hematopoietic stem cells. The treated cells started to function as they do in younger individuals. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;It rejuvenated the aging of the blood system,&#8221; added Pinho.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While this discovery doesn&#8217;t serve as an all-encompassing solution to aging, it opens new avenues for treating age-associated disorders. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;It&#8217;s clear evidence that it&#8217;s possible to reverse, intrinsically, certain age-associated disorders,&#8221; Pinho added.<\/p>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/today.uic.edu\/uic-study-of-blood-stem-cells-asks-can-we-slow-aging-on-a-cellular-level\/\" target=\"_blank\" rel=\"noopener\" title=\"\">University of Illinois Chicago<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of Illinois Chicago have made a groundbreaking discovery that could revolutionize how we understand and treat age-related disorders in the immune system. The study, published in the journal Blood, reveals that a protein called platelet factor 4, which diminishes with age, plays a crucial role in the aging process of blood [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[415],"class_list":["post-30722","post","type-post","status-publish","format-standard","hentry","category-science","tag-university-of-illinois-chicago"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers at the University of Illinois Chicago have made a groundbreaking discovery that could revolutionize how we understand and treat age-related disorders in the immune system. The study, published in the journal Blood, reveals that a protein called platelet factor 4, which diminishes with age, plays a crucial role in the aging process of blood&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30722","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=30722"}],"version-history":[{"count":5,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30722\/revisions"}],"predecessor-version":[{"id":30731,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30722\/revisions\/30731"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=30722"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=30722"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=30722"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}