{"id":30515,"date":"2025-10-10T20:35:37","date_gmt":"2025-10-10T20:35:37","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=30515"},"modified":"2025-10-10T20:42:07","modified_gmt":"2025-10-10T20:42:07","slug":"new-study-links-where-you-live-to-breast-cancer-aggressiveness","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-study-links-where-you-live-to-breast-cancer-aggressiveness\/","title":{"rendered":"New Study Links Where You Live to Breast Cancer Aggressiveness"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A groundbreaking study from the Sylvester Comprehensive Cancer Center reveals that women living near Superfund sites in Florida face increased risks of aggressive breast cancers. The research highlights the urgent need to address environmental health disparities.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Women residing near federally designated Superfund sites in Florida are significantly more likely to develop aggressive breast cancers, including the challenging-to-treat triple-negative subtype. This alarming correlation was uncovered by recent studies conducted by the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research builds on a National Institutes of Health study, which noted a rise in aggressive, treatment-resistant breast cancer forms. Sylvester researchers connected this increase to environmental factors, specifically proximity to Superfund sites \u2014 locations contaminated by hazardous waste that the Environmental Protection Agency identifies as needing urgent cleanup.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cMembers of our community raised concerns that where they lived was making people sick,\u201d Erin Kobetz<strong>,<\/strong>\u00a0an epidemiologist and associate director for community outreach and engagement at Sylvester and the Judy H. Schulte Senior Endowed Chair in Cancer Research, said in a news release. \u201cOverwhelmingly, the people who were speaking up about this lived in a neighborhood relatively close to a Superfund site. There\u2019s a growing body of evidence that living in neighborhoods close to these sites is associated with poor health outcomes.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Florida hosts 52 active Superfund sites, and the surrounding communities have been rallying for greater awareness and action. In response, Kobetz and her colleagues conducted three comprehensive studies to explore the connections between these toxic sites and breast cancer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Significant Findings<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One study analyzed over 21,000 breast cancer cases diagnosed between 2015 and 2019, assessing the impact of living near a Superfund site. The results showed a startling 30% increase in the likelihood of having metastatic breast cancer for those living close to these toxic locations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team then specifically investigated triple-negative breast cancer (TNBC), one of the most aggressive subtypes. They discovered that proximity to Superfund sites correlated with a higher risk of developing TNBC. Furthermore, they found that exposure to particulate matter 2.5 (PM2.5), a pollutant smaller than 2.5 microns, significantly raised the likelihood of TNBC.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The two studies, published in\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41598-025-05722-6\" target=\"_blank\" rel=\"noopener\" title=\"\">Scientific Reports<\/a>\u00a0and\u00a0<a href=\"https:\/\/aacrjournals.org\/cebp\/article-abstract\/doi\/10.1158\/1055-9965.EPI-25-0677\/764081\/Residential-Proximity-to-NPL-Superfund-Sites-and\" target=\"_blank\" rel=\"noopener\" title=\"\">Cancer Epidemiology Biomarkers and Prevention<\/a>, underscore the potential breast cancer risk associated with merely residing near a Superfund site.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThese studies, as well as federal funding priorities, give an increasing emphasis on the role of the environment in health outcomes,\u201d Kobetz added. \u201cWe need to better appreciate how environmental conditions may be driving variability in cancer outcomes.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Molecular Insights and Community Impact<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To delve deeper into the molecular underpinnings, the research team, co-led by Aristeidis Telonis, a research assistant professor of biochemistry and molecular biology at the Miller School of Medicine, examined genetic biomarkers of breast cancer patients from the Miami area. They compared these biomarkers to neighborhood conditions influencing health outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis deprivation index is very strongly associated with more aggressive breast cancers,\u201d Telonis said in the news release. \u201cIt\u2019s a simple, but very important correlation.\u201d <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research, <a href=\"https:\/\/aacrjournals.org\/cebp\/article-abstract\/doi\/10.1158\/1055-9965.EPI-25-0123\/764587\/Molecular-Portraits-of-Social-Adversity-in-Breast\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in Cancer Epidemiology Biomarkers and Prevention, provides groundbreaking insight into how environmental factors shape cancer at the molecular level.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Telonis and his team aim to leverage these findings to tailor personalized treatment plans considering both tumor characteristics and patients&#8217; living conditions. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe goal is that when a patient comes in, the doctor not only assesses the tumor characteristics but also considers the patient\u2019s resources and what that may mean molecularly,\u201d added Telonis. \u201cEventually, that should help inform treatment.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Towards a Healthier Future<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kobetz highlighted the importance of community involvement in driving the research forward. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;We have a signal, and we\u2019re compelled and encouraged by our Community Advisory Committee to pursue it,\u201d Kobetz said. \u201cThe community had a perspective, and now we have empirical and scientific data to suggest that their concerns may be valid. These studies are the first puzzle pieces that will help us figure out what we should be focusing on next.\u201d<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/news.med.miami.edu\/where-you-live-affects-breast-cancer-aggressiveness\/\" target=\"_blank\" rel=\"noopener\" title=\"\">University of Miami Miller School of Medicine<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Women residing near federally designated Superfund sites in Florida are significantly more likely to develop aggressive breast cancers, including the challenging-to-treat triple-negative subtype. This alarming correlation was uncovered by recent studies conducted by the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine. The research builds on a National Institutes of [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[476],"class_list":["post-30515","post","type-post","status-publish","format-standard","hentry","category-health","tag-university-of-miami-miller-school-of-medicine"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Women residing near federally designated Superfund sites in Florida are significantly more likely to develop aggressive breast cancers, including the challenging-to-treat triple-negative subtype. This alarming correlation was uncovered by recent studies conducted by the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine. The research builds on a National Institutes of&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=30515"}],"version-history":[{"count":9,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30515\/revisions"}],"predecessor-version":[{"id":30547,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30515\/revisions\/30547"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=30515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=30515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=30515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}