{"id":30373,"date":"2025-10-10T17:42:30","date_gmt":"2025-10-10T17:42:30","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=30373"},"modified":"2025-10-10T17:42:32","modified_gmt":"2025-10-10T17:42:32","slug":"hormone-replacement-therapy-may-help-boost-immune-health-in-menopausal-women","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/hormone-replacement-therapy-may-help-boost-immune-health-in-menopausal-women\/","title":{"rendered":"Hormone Replacement Therapy May Help Boost Immune Health in Menopausal Women"},"content":{"rendered":"\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A recent study reveals that hormone replacement therapy (HRT) may reverse immune system changes in menopausal women, potentially boosting immune health and reducing infection risk.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A new study led by researchers at Queen Mary University of London suggests that hormone replacement therapy (HRT) could reverse the immune system alterations caused by menopause, potentially bolstering immune health in women.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/14749726\" title=\"\">Published<\/a> in Aging Cell, the study provides new insights into how menopause dramatically impacts women\u2019s immune systems, increasing their susceptibility to infections. The researchers conducted an in-depth analysis of monocytes \u2014 a critical group of immune cells that serve as the body&#8217;s initial responders to infection \u2014 across different age groups.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study examined blood samples from younger adults (under 40 years old) and older adults (aged 65 and above). The findings revealed that post-menopausal women developed more inflammatory monocytes, which are less effective in combating bacteria. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These changes were linked to diminished levels of complement C3, a crucial immune protein that aids monocytes in destroying harmful microbes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Interestingly, men of the same age group did not exhibit these changes, indicating that menopause uniquely disrupts female immunity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOur findings highlight menopause as a critical turning point for women\u2019s immunity. While ageing affects everyone, the loss of female hormones appears to accelerate immune decline in women. Encouragingly, hormone therapy seems to restore key aspects of immune health, offering benefits that go beyond easing menopausal symptoms,\u201d lead author Emma Chambers, a senior lecturer in immunology at Queen Mary, said in a news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To assess if HRT could mitigate these immune challenges, the researchers analyzed peri- and post-menopausal women using hormone therapy. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The results indicated that these women had healthier immune profiles, marked by fewer inflammatory monocytes and enhanced infection-fighting capabilities compared to age-matched controls. Additionally, HRT appeared to elevate complement C3 levels, aligning them closer to the immune status of younger women.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe\u2019re proud to have supported this pioneering research,&#8221; added Fiona Miller Smith, chief executive of Barts Charity. &#8220;This is a brilliant example of how funding innovative ideas in health can lead to advances in our understanding \u2013 this time around menopause and women\u2019s immune systems. These findings could have a huge impact for women in our East London community and beyond.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Menopause, which generally occurs between ages 45 and 55, is often preceded by a prolonged peri-menopausal phase. The symptoms, including hot flushes, joint pain, fatigue and brain fog, can severely affect women\u2019s quality of life. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although HRT is already prescribed to manage menopausal symptoms, this study suggests it might also support immune health and lower infection risks in later life. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, the researchers emphasize the necessity of further studies to confirm if HRT effectively reduces real-world infection rates and to explore how different HRT formulations and delivery methods impact the immune system.<\/p>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/www.qmul.ac.uk\/media\/news\/2025\/medicine-and-dentistry\/fmd\/hormone-replacement-therapy-may-help-restore-immunity-in-menopausal-women-.html\" target=\"_blank\" rel=\"noopener\" title=\"\">Queen Mary University of London<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study led by researchers at Queen Mary University of London suggests that hormone replacement therapy (HRT) could reverse the immune system alterations caused by menopause, potentially bolstering immune health in women. Published in Aging Cell, the study provides new insights into how menopause dramatically impacts women\u2019s immune systems, increasing their susceptibility to infections. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[48],"class_list":["post-30373","post","type-post","status-publish","format-standard","hentry","category-health","tag-queen-mary-university-of-london"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A new study led by researchers at Queen Mary University of London suggests that hormone replacement therapy (HRT) could reverse the immune system alterations caused by menopause, potentially bolstering immune health in women. Published in Aging Cell, the study provides new insights into how menopause dramatically impacts women\u2019s immune systems, increasing their susceptibility to infections.&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=30373"}],"version-history":[{"count":7,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30373\/revisions"}],"predecessor-version":[{"id":30480,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30373\/revisions\/30480"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=30373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=30373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=30373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}