{"id":30133,"date":"2025-10-03T16:23:51","date_gmt":"2025-10-03T16:23:51","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=30133"},"modified":"2025-10-03T16:23:52","modified_gmt":"2025-10-03T16:23:52","slug":"scientists-discover-new-antibiotic-for-ibd-and-use-ai-to-predict-its-effectiveness","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/scientists-discover-new-antibiotic-for-ibd-and-use-ai-to-predict-its-effectiveness\/","title":{"rendered":"Scientists Discover New Antibiotic for IBD &#8212; and Use AI to Predict Its Effectiveness"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Researchers at McMaster University and MIT have discovered a new antibiotic, enterololin, that targets inflammatory bowel diseases. By using AI to predict its effectiveness, they significantly accelerated the drug development process, offering hope to millions affected by Crohn\u2019s disease.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-0dfbf163 wp-block-group-is-layout-flex\"><div style=\"font-size:16px;\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p>In a groundbreaking development, researchers at McMaster University and the Massachusetts Institute of Technology have unveiled a novel antibiotic, enterololin, that targets inflammatory bowel diseases (IBD), including Crohn\u2019s disease. Even more astonishing, they utilized a machine learning model to predict how the drug works, a pioneering achievement in the realm of artificial intelligence and medicine.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41564-025-02142-0\" title=\"\">Published<\/a> today in the journal Nature Microbiology, the study marks a significant leap forward in both IBD treatment and drug discovery methodology. <\/p>\n\n\n\n<p>The new antibiotic promises to revolutionize therapeutic options for millions suffering from IBD-related conditions worldwide.<\/p>\n\n\n\n<p>\u201cThis work shows that we\u2019re still just scratching the surface as far as AI-guided drug discovery goes,\u201d principal investigator Jon Stokes, an assistant professor in McMaster\u2019s Department of Biochemistry and Biomedical Sciences, said in a news release. \u201cThe development of our new drug, which is designed to target IBD, has been fast-tracked thanks to the collaboration between humans and generative AI.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Precision Treatment for IBD<\/h2>\n\n\n\n<p>Contrary to most broad-spectrum antibiotics that indiscriminately kill both harmful and beneficial bacteria, enterololin acts with surgical precision. <\/p>\n\n\n\n<p>It targets Enterobacteriaceae, a family that includes <em>E. coli<\/em>, thus avoiding collateral damage to the beneficial microbiome. <\/p>\n\n\n\n<p>This reduces the likelihood of drug-resistant bacteria colonizing the gut, a common complication with current treatments.<\/p>\n\n\n\n<p>\u201cThis new drug is a really promising treatment candidate for the millions of patients living with IBD,\u201d added Stokes. \u201cWe currently have no cure for these conditions, so developing something that might meaningfully alleviate symptoms could help people experience a much higher quality of life.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">AI\u2019s Role in Fast-Tracking Drug Discovery<\/h2>\n\n\n\n<p>Traditionally, understanding a drug&#8217;s mechanism of action (MOA) can take years and millions of dollars. This study, however, leveraged an AI model developed by MIT to predict enterololin\u2019s MOA in just 100 seconds. <\/p>\n\n\n\n<p>The subsequent validation with laboratory experiments took only six months and $60,000, as opposed to the estimated two years and $2 million that conventional methods would require.<\/p>\n\n\n\n<p>\u201cAI has expedited the rate at which we can explore chemical space for new drug candidates, but, until now, it has done little to alleviate a major bottleneck in drug development, which is understanding what these new drug candidates actually do,\u201d Stokes added.<\/p>\n\n\n\n<p>&#8220;What we\u2019re showing here is that AI can also provide mechanistic explanations, which are critical for moving a molecule through the development pipeline,\u201d added Regina Barzilay, a professor in MIT\u2019s School of Engineering who developed the AI model DiffDock, which made the prediction.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Future Prospects<\/h2>\n\n\n\n<p>The team\u2019s next steps include optimizing enterololin for human use through Stokes\u2019 spin-out company, Stoked Bio. <\/p>\n\n\n\n<p>Early trials show promise against other drug-resistant bacteria, like Klebsiella, with human trials anticipated to start within three years.<\/p>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Source:<\/strong> <a href=\"https:\/\/news.mcmaster.ca\/researchers-discover-new-antibiotic-for-ibd-and-ai-correctly-predicts-how-it-works\/\" target=\"_blank\" rel=\"noopener\" title=\"\">McMaster University<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a groundbreaking development, researchers at McMaster University and the Massachusetts Institute of Technology have unveiled a novel antibiotic, enterololin, that targets inflammatory bowel diseases (IBD), including Crohn\u2019s disease. Even more astonishing, they utilized a machine learning model to predict how the drug works, a pioneering achievement in the realm of artificial intelligence and medicine. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12,25],"tags":[256,103],"class_list":["post-30133","post","type-post","status-publish","format-standard","hentry","category-health","category-science","tag-mcmaster-university","tag-mit"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a groundbreaking development, researchers at McMaster University and the Massachusetts Institute of Technology have unveiled a novel antibiotic, enterololin, that targets inflammatory bowel diseases (IBD), including Crohn\u2019s disease. Even more astonishing, they utilized a machine learning model to predict how the drug works, a pioneering achievement in the realm of artificial intelligence and medicine.&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=30133"}],"version-history":[{"count":7,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30133\/revisions"}],"predecessor-version":[{"id":30146,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/30133\/revisions\/30146"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=30133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=30133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=30133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}