{"id":29476,"date":"2025-09-17T14:36:50","date_gmt":"2025-09-17T14:36:50","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=29476"},"modified":"2025-09-17T14:36:51","modified_gmt":"2025-09-17T14:36:51","slug":"breakthrough-study-reveals-how-exercise-aids-in-weight-loss","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/breakthrough-study-reveals-how-exercise-aids-in-weight-loss\/","title":{"rendered":"Breakthrough Study Reveals How Exercise Aids in Weight Loss"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">New research uncovers how the compound Lac-Phe, produced during intense exercise, suppresses appetite and aids in weight loss by targeting key brain neurons, paving the way for potential new weight management therapies.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers from Baylor College of Medicine, Texas Children&#8217;s Hospital, Stanford University School of Medicine and other institutions have uncovered groundbreaking insights into the ways exercise aids in weight loss. A new study <a href=\"https:\/\/www.nature.com\/articles\/s42255-025-01377-9\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in Nature Metabolism reveals that the compound Lac-Phe, produced during intense exercise, plays a crucial role in reducing appetite, thereby facilitating weight loss.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cRegular exercise is considered a powerful way to lose weight and to protect from obesity-associated diseases, such as diabetes or heart conditions,\u201d co-corresponding author Yang He, an assistant professor of pediatrics \u2013 neurology at Baylor and investigator at the Duncan NRI, said in a news release. \u201cExercise helps lose weight by increasing the amount of energy the body uses; however, it is likely that other mechanisms are also involved.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This new discovery builds on prior research that identified Lac-Phe as the most increased metabolite in the blood after rigorous exercise in mice, humans and racehorses. Previously, the research team showed that administering Lac-Phe to obese mice could curb their appetite and lead to weight loss without adverse effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Until now, however, the precise mechanism by which Lac-Phe functions was not fully understood.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Understanding how Lac-Phe works is important for developing it or similar compounds into treatments that may help people lose weight,&#8221; He added. &#8220;We looked into the brain as it regulates appetite and feeding behaviors.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team focused on two types of brain cells in mice: AgRP neurons, which promote hunger, and PVH neurons, which help suppress appetite. Typically, AgRP neurons inhibit PVH neurons, making one feel hungry. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, the study revealed that Lac-Phe directly inhibits AgRP neurons, which in turn activates PVH neurons and reduces appetite.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The absence of behavioral side effects in the mice suggests that Lac-Phe does not cause unpleasant reactions, further highlighting its potential as a therapeutic agent.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Further research showed that Lac-Phe inhibits AgRP neurons by acting on a protein called KATP channel, which is crucial in regulating cell activity. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWhen Lac-Phe activates these channels in AgRP neurons, the cells become less active,\u201d added He. \u201cWhen we blocked the KATP channels using drugs or genetic tools, Lac-Phe no longer suppressed appetite. This confirmed that the KATP channel is essential for Lac-Phe\u2019s effects.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This study sheds light on how exercise can naturally curb appetite and boost metabolism.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe results also suggest the exciting possibility of targeting this newly discovered mechanism for weight management,\u201d added co-corresponding author Yong Xu, who is currently at the University of South Florida.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis finding is important because it helps explain how a naturally produced molecule can influence appetite by interacting with a key brain region that regulates hunger and body weight,\u201d added co-corresponding author Jonathan Long, an associate professor of pathology at Stanford University School of Medicine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This promising research, although primarily conducted in mice, sets the stage for future studies to explore Lac-Phe&#8217;s effects in humans. Upcoming investigations will determine how the compound functions in different metabolic states, such as obesity versus leanness, and evaluate its safety and efficacy as a potential weight loss therapy.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/www.bcm.edu\/news\/new-study-sheds-light-on-how-exercise-helps-lose-weight\" target=\"_blank\" rel=\"noopener\" title=\"\">Baylor School of Medicine<\/a>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from Baylor College of Medicine, Texas Children&#8217;s Hospital, Stanford University School of Medicine and other institutions have uncovered groundbreaking insights into the ways exercise aids in weight loss. A new study published in Nature Metabolism reveals that the compound Lac-Phe, produced during intense exercise, plays a crucial role in reducing appetite, thereby facilitating weight [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[218,53],"class_list":["post-29476","post","type-post","status-publish","format-standard","hentry","category-science","tag-baylor-college-of-medicine","tag-stanford-university"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers from Baylor College of Medicine, Texas Children&#8217;s Hospital, Stanford University School of Medicine and other institutions have uncovered groundbreaking insights into the ways exercise aids in weight loss. A new study published in Nature Metabolism reveals that the compound Lac-Phe, produced during intense exercise, plays a crucial role in reducing appetite, thereby facilitating weight&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/29476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=29476"}],"version-history":[{"count":9,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/29476\/revisions"}],"predecessor-version":[{"id":29498,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/29476\/revisions\/29498"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=29476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=29476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=29476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}