{"id":29361,"date":"2025-09-12T14:54:39","date_gmt":"2025-09-12T14:54:39","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=29361"},"modified":"2025-09-12T14:54:41","modified_gmt":"2025-09-12T14:54:41","slug":"breakthrough-study-identifies-biomarker-that-could-detect-alzheimers-years-earlier","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/breakthrough-study-identifies-biomarker-that-could-detect-alzheimers-years-earlier\/","title":{"rendered":"Breakthrough Study Identifies Biomarker That Could Detect Alzheimer\u2019s Years Earlier"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A new study offers hope for earlier Alzheimer&#8217;s detection and intervention. Researchers found that TSPO, a brain inflammation biomarker, could identify the disease years before symptoms emerge, potentially transforming diagnosis and treatment approaches.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A groundbreaking study by researchers at Florida International University has identified a biomarker that could revolutionize the way Alzheimer&#8217;s disease is diagnosed and treated. The biomarker, TSPO (translocator protein 18 kDa), was found to indicate brain inflammation and could help detect Alzheimer&#8217;s years before significant memory loss and other symptoms manifest.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis is the first study to really examine how early this biomarker increases and where it begins rising in the brain,\u201d lead researcher Tom\u00e1s R. Guilarte, the dean of FIU\u2019s Robert Stempel College of Public Health &amp; Social Work, said in a news release. \u201cIf we can use this information to help delay Alzheimer\u2019s progression by even five years, it can drastically improve patients\u2019 lives and reduce disease prevalence.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study, <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00401-025-02912-4\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the journal Acta Neuropathologica, utilized advanced imaging software to track TSPO levels in genetically modified mouse models of familial Alzheimer\u2019s. These findings were corroborated using human brain tissue donated by families from Antioquia, Colombia. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These families carry the \u201cpaisa\u201d mutation and are part of the largest known group of individuals with early-onset familial Alzheimer\u2019s, first identified by the late Francisco Lopera, a co-author of the study.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For individuals with this mutation, symptoms usually appear in their 30s or 40s, and they typically die in their 50s.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the mouse models, the researchers discovered elevated TSPO levels in the subiculum \u2014 a critical part of the hippocampus \u2014 as early as six weeks of age. This timeline is roughly equivalent to age 18\u201320 in humans. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Significantly higher levels of TSPO were found in microglia, the brain\u2019s immune cells, especially those near amyloid plaques. Female mice displayed even higher TSPO levels, reflecting the fact that two-thirds of Alzheimer\u2019s patients are women.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The brain tissue samples from the Colombian patients carrying the paisa mutation exhibited a similar pattern. Even in advanced stages of Alzheimer\u2019s, TSPO levels remained elevated in microglia near plaques. These findings prompt new questions about the role of TSPO &#8212; does it contribute to damage or help protect the brain? And could modulating TSPO, either by blocking or enhancing it, potentially slow down disease progression?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research team is now exploring these questions using a specialized Alzheimer&#8217;s mouse model that lacks TSPO. They are also broadening their research to include sporadic, late-onset Alzheimer\u2019s cases, which make up over 90% of all diagnoses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe more we understand these processes,\u201d added first author Daniel Mart\u00ednez P\u00e9rez,  a doctoral candidate in Guilarte\u2019s lab, \u201cthe closer we get to tailoring treatments that can truly help &#8212; before it\u2019s too late.\u201d<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/www.eurekalert.org\/news-releases\/1098054\" target=\"_blank\" rel=\"noopener\" title=\"\">Florida Atlantic University<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A groundbreaking study by researchers at Florida International University has identified a biomarker that could revolutionize the way Alzheimer&#8217;s disease is diagnosed and treated. The biomarker, TSPO (translocator protein 18 kDa), was found to indicate brain inflammation and could help detect Alzheimer&#8217;s years before significant memory loss and other symptoms manifest. \u201cThis is the first [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[58],"class_list":["post-29361","post","type-post","status-publish","format-standard","hentry","category-health","tag-florida-atlantic-university"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A groundbreaking study by researchers at Florida International University has identified a biomarker that could revolutionize the way Alzheimer&#8217;s disease is diagnosed and treated. The biomarker, TSPO (translocator protein 18 kDa), was found to indicate brain inflammation and could help detect Alzheimer&#8217;s years before significant memory loss and other symptoms manifest. \u201cThis is the first&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/29361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=29361"}],"version-history":[{"count":9,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/29361\/revisions"}],"predecessor-version":[{"id":29377,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/29361\/revisions\/29377"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=29361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=29361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=29361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}