{"id":27370,"date":"2025-07-18T17:40:55","date_gmt":"2025-07-18T17:40:55","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=27370"},"modified":"2025-07-18T17:40:57","modified_gmt":"2025-07-18T17:40:57","slug":"new-ai-model-can-speed-up-alzheimers-drug-discovery","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-ai-model-can-speed-up-alzheimers-drug-discovery\/","title":{"rendered":"New AI Model Can Speed Up Alzheimer&#8217;s Drug Discovery"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A revolutionary AI model from the University of Cambridge reshapes Alzheimer&#8217;s clinical trials, enabling targeted treatments and accelerating drug discovery, potentially bringing hope to millions.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A team of scientists at the University of Cambridge has developed an artificial intelligence model capable of transforming how clinical trials for Alzheimer\u2019s disease are conducted. The groundbreaking model can predict the progression of cognitive decline in patients three times more accurately than standard clinical tests.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The AI was used to reanalyze data from a completed clinical trial of an Alzheimer\u2019s drug, revealing the drug slowed cognitive decline by 46% in patients with early-stage, slow-progressing mild cognitive impairment. This condition often progresses to Alzheimer\u2019s, marking a significant find for early intervention strategies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cPromising new drugs fail when given to people too late, when they have no chance of benefiting from them. With our AI model we can finally identify patients precisely, and match the right patients to the right drugs,&#8221; senior author Zoe Kourtzi, a professor&nbsp;in the University of Cambridge\u2019s Department of Psychology, said in a news release. &#8220;This makes trials more precise, so they can progress faster and cost less, turbocharging the search for a desperately-need precision medicine approach for dementia treatment.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study, <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-61355-3\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the journal Nature Communications, demonstrates that precise patient stratification \u2014 dividing patients into slow or rapidly progressing groups \u2014 enables more efficient and cost-effective clinical trials. By focusing on those most likely to benefit, the AI model can enhance the accuracy and speed of drug development.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;With our AI model, trials become more precise, so they can progress faster and cost less, turbocharging the search for a desperately-needed precision medicine approach for dementia treatment,&#8221; Kourtzi added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The AI model helps scientists interpret the efficacy of drugs in patients&#8217; groups by tracking the reduction of beta-amyloid proteins in the brain \u2014 a key marker of Alzheimer\u2019s disease. This new approach could streamline the drug development process, making it faster and cheaper, improving the chances of finding effective treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Health Innovation East England, the innovation arm of the National Health Service in East England, is collaborating with Kourtzi to implement the AI model into clinical practice. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;This AI-enabled approach could have a significant impact on easing NHS pressure and costs in dementia care by enabling more personalized drug development \u2014 identifying which patients are most likely to benefit from treatment, resulting in faster access to effective medicines and targeted support for people living with dementia,&#8221; added Joanna Dempsey, principal advisor at Health Innovation East England.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dementia is a significant global health concern, costing $1.3 trillion annually. Despite substantial investment in research, over 95% of dementia drug trials fail, partly due to variations in disease progression and treatment response.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;AI can guide us to the patients who will benefit from dementia medicines, by treating them at the stage when the drugs will make a difference, so we can finally start fighting back against these cruel diseases,&#8221; Kourtzi added. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The AI model&#8217;s potential to reduce the time and cost of clinical trials by accurately targeting responsive patients is a beacon of hope for accelerating the discovery of effective Alzheimer&#8217;s treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cLike many people, I have watched hopelessly as dementia stole a loved one from me. \u00a0We\u2019ve got to accelerate the development of dementia medicines,&#8221; added Kourtzi. &#8220;Over \u00a340 billion has already been spent over 30 years of research and development &#8212; we can\u2019t wait another 30 years.\u201d<\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/www.cam.ac.uk\/research\/news\/ai-can-accelerate-search-for-more-effective-alzheimers-medicines-by-streamlining-clinical-trials\" target=\"_blank\" rel=\"noopener\" title=\"\">University of Cambridge<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of scientists at the University of Cambridge has developed an artificial intelligence model capable of transforming how clinical trials for Alzheimer\u2019s disease are conducted. The groundbreaking model can predict the progression of cognitive decline in patients three times more accurately than standard clinical tests. The AI was used to reanalyze data from a [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[8],"tags":[188],"class_list":["post-27370","post","type-post","status-publish","format-standard","hentry","category-ai","tag-university-of-cambridge"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A team of scientists at the University of Cambridge has developed an artificial intelligence model capable of transforming how clinical trials for Alzheimer\u2019s disease are conducted. The groundbreaking model can predict the progression of cognitive decline in patients three times more accurately than standard clinical tests. The AI was used to reanalyze data from a&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/27370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=27370"}],"version-history":[{"count":10,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/27370\/revisions"}],"predecessor-version":[{"id":27402,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/27370\/revisions\/27402"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=27370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=27370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=27370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}