{"id":25844,"date":"2025-06-11T15:44:26","date_gmt":"2025-06-11T15:44:26","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=25844"},"modified":"2025-06-11T15:44:28","modified_gmt":"2025-06-11T15:44:28","slug":"pancreatic-cancer-vaccine-shows-remarkable-results-in-preclinical-trials","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/pancreatic-cancer-vaccine-shows-remarkable-results-in-preclinical-trials\/","title":{"rendered":"Pancreatic Cancer Vaccine Shows Remarkable Results in Preclinical Trials"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A pioneering vaccine targeting pancreatic cancer has shown remarkable results in preclinical trials, potentially paving the way for new treatment options for the deadliest form of cancer.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers at Case Western Reserve University and Cleveland Clinic have created a vaccine that has eliminated pancreatic cancer in preclinical models of pancreatic ductal adenocarcinoma (PDAC), the most common form of the disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pancreatic cancer remains one of the deadliest forms of cancer, with a grim five-year survival rate of just 13%, according to the American Cancer Society. The disease typically goes unnoticed until it has metastasized, making early detection challenging. Standard treatments such as surgery, radiation and chemotherapy rarely result in a cure, often only extending survival. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cPancreatic cancer is super aggressive,\u201d Zheng-Rong Lu, the M. Frank Rudy and Margaret C. Rudy Professor of Biomedical Engineering at the Case School of Engineering, said in a news release. \u201cSo it came as a surprise that our approach works so well.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lu teamed up with immunologist\u00a0Li Lily Wang,\u00a0an associate professor of molecular medicine at the Case Western Reserve School of Medicine, to develop a vaccine that utilizes nanoparticles containing antigens, which serve as markers to help the immune system identify and attack cancer cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis platform has the potential to transform clinical care for this devastating disease,\u201d added Wang, who is also a staff member in translational hematology and oncology research at Cleveland Clinic. \u201cI am excited to see that our novel nano-vaccine worked so well in eliciting vigorous responses from tumor-reactive T cells \u2014 which are typically low in numbers and unable to control tumor growth.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Over two decades of Lu\u2019s research on lipid-based nanoparticles \u2014 well-tolerated and compatible with living tissue \u2014 have culminated in this innovative vaccine. The nanoparticles stimulate the immune system by targeting oncogenes commonly mutated in PDAC cells, training the body to recognize and destroy these tumor cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The vaccines have shown impressive results, with over half of the preclinical models remaining cancer-free months after treatment. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Such results offer a potentially transformative approach to managing PDAC \u2014 not only as a therapy but possibly as a preventive measure for those genetically predisposed to the disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe\u2019ve shown that our vaccine generated immune memory in preclinical models,\u201d Lu added. \u201cIf we could do that in patients, we could prevent PDAC before tumors start forming, so the vaccines could be either therapeutic or preventative.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers are planning to enhance the vaccine\u2019s efficacy by combining it with immune checkpoint inhibitors, which help maintain the immune response against cancer cells. These inhibitors are already used in treating various cancers and could further improve the outcomes when used alongside the new vaccine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Supported by a $3.27 million, five-year grant from the National Cancer Institute, the team will continue exploring the therapeutic potential of the vaccine in PDAC. Lu aims to collaborate with industry partners to ensure safety in other models before progressing to clinical trials in human patients.<\/p>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/www.eurekalert.org\/news-releases\/1086995\" target=\"_blank\" rel=\"noopener\" title=\"\">Case Western Reserve University<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Case Western Reserve University and Cleveland Clinic have created a vaccine that has eliminated pancreatic cancer in preclinical models of pancreatic ductal adenocarcinoma (PDAC), the most common form of the disease. Pancreatic cancer remains one of the deadliest forms of cancer, with a grim five-year survival rate of just 13%, according to the [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[203],"class_list":["post-25844","post","type-post","status-publish","format-standard","hentry","category-health","tag-case-western-reserve-university"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers at Case Western Reserve University and Cleveland Clinic have created a vaccine that has eliminated pancreatic cancer in preclinical models of pancreatic ductal adenocarcinoma (PDAC), the most common form of the disease. Pancreatic cancer remains one of the deadliest forms of cancer, with a grim five-year survival rate of just 13%, according to the&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/25844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=25844"}],"version-history":[{"count":12,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/25844\/revisions"}],"predecessor-version":[{"id":25921,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/25844\/revisions\/25921"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=25844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=25844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=25844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}