{"id":25651,"date":"2025-06-06T18:33:36","date_gmt":"2025-06-06T18:33:36","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=25651"},"modified":"2025-06-06T18:35:12","modified_gmt":"2025-06-06T18:35:12","slug":"new-drug-delivery-system-targets-lungs-to-treat-cancer-cystic-fibrosis","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-drug-delivery-system-targets-lungs-to-treat-cancer-cystic-fibrosis\/","title":{"rendered":"New Drug Delivery System Targets Lungs to Treat Cancer, Cystic Fibrosis"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Scientists have made a significant breakthrough by developing a nanoparticle delivery system capable of transporting genetic therapies directly to the lungs, potentially transforming treatment options for lung cancer and cystic fibrosis.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A revolutionary development in genetic therapy has emerged from Oregon State University (OSU), offering new hope for patients with lung cancer and cystic fibrosis. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Spearheaded by Gaurav Sahay from OSU\u2019s College of Pharmacy, in collaboration with Oregon Health &amp; Science University and the University of Helsinki, researchers have devised a novel nanoparticle-based drug delivery system that can safely and effectively transport genetic therapies directly to lung cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Significant New Findings Published<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The breakthrough findings are detailed in two papers published in <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-59136-z\" target=\"_blank\" rel=\"noopener\" title=\"\">Nature Communications<\/a> and the <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c04123\" target=\"_blank\" rel=\"noopener\" title=\"\">Journal of the American Chemical Society<\/a>. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Through comprehensive experimentation involving over 150 different materials, scientists have identified a new class of nanoparticles capable of carrying messenger RNA (mRNA) and gene-editing tools to the lungs. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Remarkably, this innovation has shown promise in slowing lung cancer growth and enhancing lung function impaired by cystic fibrosis in mouse models.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe streamlined synthesis method makes it easier to design future therapies for a wide range of diseases,\u201d Sahay said in a news release. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A Broad Library of Lung-Targeting Lipids<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One of the study&#8217;s crucial advancements includes the development of a chemical strategy to synthesize a diverse library of lung-targeting lipids. These lipids form the core of the nanoparticle carriers and can be customized to target various organs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThese results demonstrate the power of targeted delivery for genetic medicines. We were able to both activate the immune system to fight cancer and restore function in a genetic lung disease, without harmful side effects,\u201d added Sahay.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Collaboration and Future Directions<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The Nature Communications paper lists Oregon State\u2019s K. Yu Vlasova, D.K. Sahel, Namratha Turuvekere Vittala Murthy, Milan Gautam and Antony Jozic as co-authors, working alongside scientists from OHSU and the University of Helsinki.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Journal of the American Chemical Society publication includes contributions from OSU\u2019s Murthy, Jonas Renner, Milan Gautam, Emily Bodi and Antony Jozic, with Sahay leading the research efforts.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOur long-term goal is to create safer, more effective treatments by delivering the right genetic tools to the right place,\u201d Sahay noted. \u201cThis is a major step in that direction.\u201d<\/p>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/news.oregonstate.edu\/news\/new-genetic-delivery-system-targets-lungs-treat-cancer-cystic-fibrosis\" target=\"_blank\" rel=\"noopener\" title=\"\">Oregon State University<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A revolutionary development in genetic therapy has emerged from Oregon State University (OSU), offering new hope for patients with lung cancer and cystic fibrosis. Spearheaded by Gaurav Sahay from OSU\u2019s College of Pharmacy, in collaboration with Oregon Health &amp; Science University and the University of Helsinki, researchers have devised a novel nanoparticle-based drug delivery system [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[387,181,100],"class_list":["post-25651","post","type-post","status-publish","format-standard","hentry","category-science","tag-oregon-health-science-university","tag-oregon-state-university","tag-university-of-helsinki"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A revolutionary development in genetic therapy has emerged from Oregon State University (OSU), offering new hope for patients with lung cancer and cystic fibrosis. Spearheaded by Gaurav Sahay from OSU\u2019s College of Pharmacy, in collaboration with Oregon Health &amp; Science University and the University of Helsinki, researchers have devised a novel nanoparticle-based drug delivery system&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/25651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=25651"}],"version-history":[{"count":12,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/25651\/revisions"}],"predecessor-version":[{"id":25669,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/25651\/revisions\/25669"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=25651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=25651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=25651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}