{"id":24857,"date":"2025-05-29T15:19:41","date_gmt":"2025-05-29T15:19:41","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=24857"},"modified":"2025-05-29T15:19:43","modified_gmt":"2025-05-29T15:19:43","slug":"new-study-links-weight-loss-to-specific-brain-cells","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-study-links-weight-loss-to-specific-brain-cells\/","title":{"rendered":"New Study Links Weight Loss to Specific Brain Cells"},"content":{"rendered":"\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">In a significant breakthrough, researchers at the University of Gothenburg have discovered specific brain cells that mediate semaglutide&#8217;s weight loss effects while minimizing side effects. This could lead to better obesity treatments.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a groundbreaking study, scientists at the University of Gothenburg have identified a specific group of nerve cells in the brain stem that control the appetite and weight-loss effects of semaglutide, a widely used obesity and type 2 diabetes drug. This discovery could herald a new era in obesity treatment by minimizing the drug\u2019s side effects such as nausea.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers set out to understand how semaglutide impacts the brain. Semaglutide belongs to a class of drugs called GLP-1R agonists, known for effectively reducing food intake and body weight but often causing undesirable side effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis suggests that these nerve cells control the beneficial effects of semaglutide. We have therefore identified a specific group of nerve cells that is necessary for the effects that semaglutide has on weight and appetite, but which does not appear to contribute to any significant extent to side effects such as nausea. If we can target the treatment there, we may be able to maintain the positive effects while reducing side effects,&#8221; first author J\u00falia Teixidor-Deulofeu, a doctoral student at the University of Gothenburg&#8217;s Sahlgrenska Academy, said in a news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413125002566\" target=\"_blank\" rel=\"noopener\" title=\"\">Published<\/a> in the journal Cell Metabolism, the study revealed that the targeted nerve cells are located in the dorsal vagal complex of the brain. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers were able to track which nerve cells were activated by the drug by conducting experiments on mice, leading them to the discovery that simulating the activation of these cells \u2014 without administering the drug itself \u2014 could induce similar effects of reduced food intake and weight loss.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Semaglutide and other GLP-1R agonists are currently being prescribed to more and more people and are also being investigated for other potential indications such as substance use disorders and neurodegenerative diseases. It is important to understand how these drugs actually work. The better we understand this, the greater the opportunity we have to improve them,&#8221; added corresponding author, Linda Engstr\u00f6m Ruud, a researcher who supervised Teixidor-Deulofeu and\u00a0co-author Sebastian Blid Sk\u00f6ldheden, a doctoral student. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This new understanding not only opens the door to potentially more effective and tolerable obesity treatments but also enriches the scientific community\u2019s knowledge of how the brain stem regulates energy balance. By targeting the beneficial nerve cells while avoiding the ones causing side effects, future drugs could offer a profoundly improved quality of life for patients struggling with obesity and related metabolic disorders.<\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/www.gu.se\/en\/news\/weight-loss-linked-to-nerve-cells-in-the-brain\" target=\"_blank\" rel=\"noopener\" title=\"\">University of Gothenburg<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a groundbreaking study, scientists at the University of Gothenburg have identified a specific group of nerve cells in the brain stem that control the appetite and weight-loss effects of semaglutide, a widely used obesity and type 2 diabetes drug. This discovery could herald a new era in obesity treatment by minimizing the drug\u2019s side [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[169],"class_list":["post-24857","post","type-post","status-publish","format-standard","hentry","category-science","tag-university-of-gothenburg"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a groundbreaking study, scientists at the University of Gothenburg have identified a specific group of nerve cells in the brain stem that control the appetite and weight-loss effects of semaglutide, a widely used obesity and type 2 diabetes drug. This discovery could herald a new era in obesity treatment by minimizing the drug\u2019s side&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=24857"}],"version-history":[{"count":7,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24857\/revisions"}],"predecessor-version":[{"id":25045,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24857\/revisions\/25045"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=24857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=24857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=24857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}