{"id":24450,"date":"2025-05-20T14:17:51","date_gmt":"2025-05-20T14:17:51","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=24450"},"modified":"2025-05-20T17:42:29","modified_gmt":"2025-05-20T17:42:29","slug":"new-affordable-blood-test-for-early-alzheimers-detection","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-affordable-blood-test-for-early-alzheimers-detection\/","title":{"rendered":"New Affordable Blood Test for Early Alzheimer\u2019s Detection"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">USC scientists have unveiled a new blood test to detect Alzheimer\u2019s disease early. This affordable and accessible test, which measures five biomarkers, could revolutionize how the disease is diagnosed and treated.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers from the Keck School of Medicine at the University of Southern California (USC) have made a significant breakthrough in the early detection of Alzheimer\u2019s disease with the development of a cost-effective blood test. Known as the Penta-Plex Alzheimer\u2019s Disease Capture Sandwich Immunoassay (5ADCSI), this test measures five crucial biomarkers linked to Alzheimer\u2019s, offering an economic and accessible solution for early diagnosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The new test can identify the presence of amyloid and tau, proteins that accumulate in the brain and blood as Alzheimer&#8217;s progresses. Unlike its expensive predecessors that require specialized equipment and can only detect a few biomarkers, 5ADCSI utilizes the widely available xMAP\u00ae technology from Luminex. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This advancement promises to bring annual Alzheimer&#8217;s screenings into routine medical practice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe biggest advantage is that our test is very cost-effective compared to other existing technologies, and it\u2019s relatively easy to implement because many laboratories in universities, hospitals and clinics are already using this technology,\u201d Ebrahim Zandi, an associate professor of molecular microbiology and immunology at the Keck School of Medicine who led the research, said in a news release.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Early Detection, Early Intervention<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The importance of early detection in Alzheimer&#8217;s cannot be overstated. Current treatments are most effective when applied at the earliest stages, before significant cognitive decline. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The 5ADCSI test, with its affordability and ease of use, could make widespread early detection feasible. This timely identification enables interventions that might delay or even prevent the onset of severe symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cIn the 10 to 20 years Alzheimer\u2019s takes to develop, proteins such as amyloid and tau are slowly building up,\u201d Zandi added. \u201cIf we have an affordable blood test that detects those proteins early on, we can start interventions long before symptoms begin.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Development and Testing<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The research team meticulously chose biomarkers known to accumulate with Alzheimer&#8217;s: amyloid-beta 40, amyloid-beta 42, phosphorylated tau (p217Tau), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Using xMAP\u00ae technology, they developed a custom assay for these biomarkers. The test involves color-coded beads coated with antibodies that bind to these proteins in a blood sample. The biomarkers are then identified using powerful imaging sensors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a proof-of-concept study, funded by the National Institutes of Health and <a href=\"https:\/\/journals.sagepub.com\/eprint\/WKERYYHZ6JYVQI66YPTA\/full\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the Journal of Alzheimer\u2019s Disease, the researchers validated the test&#8217;s effectiveness by measuring biomarkers in 63 blood samples. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These samples came from three groups: patients with Alzheimer&#8217;s, individuals with mild cognitive impairment and healthy participants. The highest levels of biomarkers were found in those with Alzheimer\u2019s.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Further tests compared blood biomarker levels to those in cerebrospinal fluid (CSF), the latter being more challenging and costly to collect. The strong correlations found validate the test\u2019s sensitivity and capability for early detection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Future Prospects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Christopher Beam, an associate professor of psychology at the USC Dornsife College of Letters, Arts and Sciences, highlighted how this innovation serves both research and clinical needs. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Initially developed for research purposes, the team aims to refine the test for clinical settings, planning larger studies to confirm its accuracy across a broader patient population.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zandi and his colleagues envision the test becoming a standard component of annual check-ups, rivaling cholesterol and blood sugar tests. He aims to expand the test\u2019s utility by integrating genetic testing for APOE4, a gene variant associated with Alzheimer&#8217;s, enabling comprehensive brain health risk assessments.<\/p>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/keck.usc.edu\/news\/usc-researchers-develop-low-cost-blood-test-for-early-alzheimers-detection\/\" target=\"_blank\" rel=\"noopener\" title=\"\">Keck School of Medicine, University of Southern California<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the Keck School of Medicine at the University of Southern California (USC) have made a significant breakthrough in the early detection of Alzheimer\u2019s disease with the development of a cost-effective blood test. Known as the Penta-Plex Alzheimer\u2019s Disease Capture Sandwich Immunoassay (5ADCSI), this test measures five crucial biomarkers linked to Alzheimer\u2019s, offering an [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[40],"class_list":["post-24450","post","type-post","status-publish","format-standard","hentry","category-health","tag-university-of-southern-california"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers from the Keck School of Medicine at the University of Southern California (USC) have made a significant breakthrough in the early detection of Alzheimer\u2019s disease with the development of a cost-effective blood test. Known as the Penta-Plex Alzheimer\u2019s Disease Capture Sandwich Immunoassay (5ADCSI), this test measures five crucial biomarkers linked to Alzheimer\u2019s, offering an&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=24450"}],"version-history":[{"count":10,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24450\/revisions"}],"predecessor-version":[{"id":24668,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24450\/revisions\/24668"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=24450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=24450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=24450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}