{"id":24234,"date":"2025-05-14T20:52:29","date_gmt":"2025-05-14T20:52:29","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=24234"},"modified":"2025-05-14T20:52:31","modified_gmt":"2025-05-14T20:52:31","slug":"new-genetic-test-to-boost-ivf-success-rates","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-genetic-test-to-boost-ivf-success-rates\/","title":{"rendered":"New Genetic Test to Boost IVF Success Rates"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Researchers led by Lund University have unveiled a simple genetic test using a painless oral swab that could revolutionize IVF treatments by increasing success rates and reducing side effects. The innovative swab test determines the most suitable hormone therapy based on a woman&#8217;s genetic profile.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A new study from Lund University, <a href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2025.1576090\/full\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in Frontiers in Endocrinology, promises to revolutionize in vitro fertilization (IVF) by introducing a simple genetic test that significantly increases success rates and reduces severe side effects. The test aims to tailor hormone treatments according to a woman&#8217;s genetic makeup, potentially increasing pregnancy rates and live births.<\/p>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">About 15% of couples of reproductive age face involuntary childlessness, and many turn to IVF for assistance \u2014 a trend expected to rise globally. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;In Europe alone, 1 million IVF treatments are carried out each year; in Sweden, the corresponding number is 25,000,&#8221; lead researcher Yvonne Lundberg Giwercman, a professor at Lund University, said in a news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Currently, IVF involves stimulating the ovaries with powerful hormone treatments to mature eggs, which are then fertilized in a lab before being implanted back into the uterus. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But the process is fraught with risks, including serious side effects and a high failure rate. Up to 75% of IVF attempts fail, and 20% of patients experience adverse effects that can require emergency care.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;There is an over-reliance on IVF treatments,&#8221; added first author Ida Hjelm\u00e9r, a laboratory researcher at Lund University. &#8220;A major challenge is that healthcare today to some extent has to guess which treatment is best for the woman.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers focused on genetics to uncover why different women respond differently to hormone treatments. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a randomized clinical trial involving 1,466 women undergoing IVF, the team found a significant genetic marker: a variant in the follicle-stimulating hormone receptor (FSHR) gene. Women with this variant responded better to biological hormone treatments, while others benefited more from synthetic hormones.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By understanding a patient&#8217;s genetic profile, treatments can be personalized, thereby increasing the chances of successful pregnancy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;We see an increase in the number of pregnancies and a relative number of 38% more babies born among women who received hormone therapy that matched their gene variation compared with those who did not,&#8221; Giwercman added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team has now developed an easy-to-use oral swab test that reveals the most suitable hormone treatment within an hour. The result is apparent to the naked eye as a pink or yellow color. This test paves the way for more efficient and less risky IVF treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team has filed a patent application for the test and founded a company,  Dx4Life AB, to commercialize the test.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Our hope is that this will reduce the risk of suffering for women, increase the number of successful treatments and cut costs for taxpayers,&#8221; added Giwercman, who is also the CEO of Dx4Life AB, the company founded to commercialize the test. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team&#8217;s goal is to have the test available by early 2026.<\/p>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source:<\/strong> <a href=\"https:\/\/www.lunduniversity.lu.se\/article\/higher-success-rate-using-simple-oral-swab-test-ivf\" target=\"_blank\" rel=\"noopener\" title=\"\">Lund University<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study from Lund University, published in Frontiers in Endocrinology, promises to revolutionize in vitro fertilization (IVF) by introducing a simple genetic test that significantly increases success rates and reduces severe side effects. The test aims to tailor hormone treatments according to a woman&#8217;s genetic makeup, potentially increasing pregnancy rates and live births. About [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[25],"tags":[242],"class_list":["post-24234","post","type-post","status-publish","format-standard","hentry","category-science","tag-lund-university"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Researchers led by Lund University have developed a simple genetic test using an oral swab to significantly increase IVF success rates and reduce side effects.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"The University Network\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.tun.com\/home\/new-genetic-test-to-boost-ivf-success-rates\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"TUN - 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The test aims to tailor hormone treatments according to a woman&#8217;s genetic makeup, potentially increasing pregnancy rates and live births. About&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=24234"}],"version-history":[{"count":24,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24234\/revisions"}],"predecessor-version":[{"id":24385,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/24234\/revisions\/24385"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=24234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=24234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=24234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}