{"id":20881,"date":"2025-03-27T19:04:49","date_gmt":"2025-03-27T19:04:49","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=20881"},"modified":"2025-03-27T19:04:51","modified_gmt":"2025-03-27T19:04:51","slug":"lupus-related-antibody-offers-new-hope-for-hard-to-treat-cancers","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/lupus-related-antibody-offers-new-hope-for-hard-to-treat-cancers\/","title":{"rendered":"Lupus-Related Antibody Offers New Hope for Hard-to-Treat Cancers"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Yale scientists have discovered a lupus-related antibody that can trigger immune responses in hard-to-treat cancers, offering new hope for therapies against glioblastoma and other aggressive tumors.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a groundbreaking study, Yale University scientists have identified a promising new way to activate immune responses against certain difficult-to-treat tumors. The research, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scisignal.adk3320\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in Science Signaling, reveals that a lupus-related antibody can infiltrate &#8220;cold&#8221; tumors, which typically evade the immune system, and activate an immune response.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cIt turns out when this antibody gets into the cell\u2019s cytoplasm [the liquid material inside the cell, excluding the nucleus] and it binds to RNA, it causes this thing called a pattern recognition receptor to wake up and say, \u2018This isn&#8217;t supposed to be here,\u2019 which triggers an immune reaction,\u201d senior author James Hansen, the radiology oncology chief of Yale&#8217;s Gamma Knife Program and a member of the Yale Cancer Center, said in a news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By leveraging this antibody, researchers have been able to prolong survival in brain tumor models without the need for traditional treatments like radiation or chemotherapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cold tumors, often referred to as immune deserts, are challenging to treat because they lack immune cells such as T cells. This makes them unresponsive to most cancer treatments, including immunotherapies that rely on the presence of these cells. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Conversely, &#8220;hot tumors&#8221; do respond to treatments since they have immune cells, even if those cells are temporarily suppressed by the cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe\u2019re excited about this new way to engage the immune system to treat brain tumors,\u201d added Hansen. \u201cEqually exciting is the discovery that this lupus antibody delivers genes to cells without needing any help from a virus, meaning it could be used to transform gene therapy strategies.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study confirms that the antibody is ineffective in tissue that lacks functional immune cells. However, when immune cells function correctly, the antibody can deliver functional RNA into tumor, brain and muscle tissue. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This finding could revolutionize non-viral gene delivery methods, which utilize physical forces rather than viruses to introduce genetic material into cells, and provide new avenues for immunotherapy treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Joining Hansen in this groundbreaking research was first author Xiaoyong Chen of Yale. The collaborative effort included contributions from 12 other Yale scientists, as well as researchers from UCLA and the Veterans Affairs Greater Los Angeles Healthcare System.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This breakthrough has the potential to significantly enhance the efficacy of current cancer treatments, transforming how aggressive cancers like glioblastoma are treated and providing a beacon of hope for patients worldwide.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/medicine.yale.edu\/news-article\/lupus-related-antibody-shows-promise-in-enhancing-cancer-treatment-efficacy\/\" target=\"_blank\" rel=\"noopener\" title=\"\">Yale School of Medicine<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a groundbreaking study, Yale University scientists have identified a promising new way to activate immune responses against certain difficult-to-treat tumors. The research, published in Science Signaling, reveals that a lupus-related antibody can infiltrate &#8220;cold&#8221; tumors, which typically evade the immune system, and activate an immune response. \u201cIt turns out when this antibody gets into [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[202,102],"class_list":["post-20881","post","type-post","status-publish","format-standard","hentry","category-science","tag-ucla","tag-yale-university"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a groundbreaking study, Yale University scientists have identified a promising new way to activate immune responses against certain difficult-to-treat tumors. The research, published in Science Signaling, reveals that a lupus-related antibody can infiltrate &#8220;cold&#8221; tumors, which typically evade the immune system, and activate an immune response. \u201cIt turns out when this antibody gets into&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/20881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=20881"}],"version-history":[{"count":10,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/20881\/revisions"}],"predecessor-version":[{"id":21102,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/20881\/revisions\/21102"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=20881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=20881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=20881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}