{"id":20879,"date":"2025-03-26T18:16:48","date_gmt":"2025-03-26T18:16:48","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=20879"},"modified":"2025-03-26T18:18:27","modified_gmt":"2025-03-26T18:18:27","slug":"early-combination-therapy-reduces-cardiovascular-risks","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/early-combination-therapy-reduces-cardiovascular-risks\/","title":{"rendered":"Early Combination Therapy Reduces Cardiovascular Risks: New Study"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A new study highlights the superior benefits of using combination lipid-lowering therapy with statins and ezetimibe over statin monotherapy to reduce cardiovascular risks and mortality.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a significant breakthrough for cardiovascular health, Dr. Carl J. &#8220;Chip&#8221; Lavie, Jr., a medical director for cardiac rehabilitation and preventive cardiology at Ochsner Health, has co-authored an influential new study advocating for the early adoption of combination lipid-lowering therapy. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0025619625000758\" target=\"_blank\" rel=\"noopener\" title=\"\">Published<\/a> in the journal Mayo Clinic Proceedings, this research explores the comparative efficacy of using statins together with ezetimibe versus statin monotherapy and yields promising findings for high-risk patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Led by Maciej Banach, head for the Bureau for the International Collaboration and Development at the Medical University of Lodz\u00a0in Poland and head of the International Lipid Expert Panel (ILEP), the comprehensive meta-analysis aggregated data from 14 studies involving over 108,000 high-risk individuals. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This review demonstrated that combining statins with ezetimibe not only achieved superior LDL cholesterol reduction \u2013 averaging a mean difference of -12.96 mg\/dL \u2013 but also significantly decreased all-cause mortality by 19%, major adverse cardiovascular events by 18% and stroke incidence by 17%.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;The findings underscore the importance of a proactive, combination-based strategy in lipid-lowering therapy,&#8221; Lavie said in a news release. &#8220;By optimizing LDL-C reductions early, we can dramatically improve patient outcomes and reduce the global burden of cardiovascular disease.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The analysis accentuated that the safety profile of combination therapy is comparable to that of statin monotherapy, with similar risks of adverse effects and therapy discontinuation. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This revelation positions combination therapy as a practical, safe option for clinicians aiming to achieve target LDL-C levels and significantly curtail cardiovascular mortality and morbidity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study marks a pivotal shift in preventative cardiology, recommending integration of combination therapy early in treatment plans, especially for individuals deemed high or very high risk. By preemptively adopting this strategy, clinicians can not only strive for LDL-C target benchmarks more efficiently but also substantially elevate patient outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lavie, along with his colleagues, envisions this early intervention across the board \u2013 even prior to any manifest cardiovascular events \u2013 to be a strategic pivot point in managing cardiovascular health. As cardiovascular diseases continue to be a leading cause of death globally, the application of such proactive, combinatory treatments holds the promise of saving countless lives.<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: <\/strong><a href=\"https:\/\/www.eurekalert.org\/news-releases\/1078153\" target=\"_blank\" rel=\"noopener\" title=\"\">Ochsner Health System<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a significant breakthrough for cardiovascular health, Dr. Carl J. &#8220;Chip&#8221; Lavie, Jr., a medical director for cardiac rehabilitation and preventive cardiology at Ochsner Health, has co-authored an influential new study advocating for the early adoption of combination lipid-lowering therapy. Published in the journal Mayo Clinic Proceedings, this research explores the comparative efficacy of using [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[27],"tags":[214,215],"class_list":["post-20879","post","type-post","status-publish","format-standard","hentry","category-health-care","tag-medical-university-of-lodz","tag-ochsner-health-system"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"A recent study reveals that combining statins with ezetimibe significantly lowers cardiovascular risks and mortality compared to statin monotherapy.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"The University Network\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.tun.com\/home\/early-combination-therapy-reduces-cardiovascular-risks\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"TUN - 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