{"id":17598,"date":"2025-02-12T20:30:34","date_gmt":"2025-02-12T20:30:34","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=17598"},"modified":"2025-02-12T20:30:35","modified_gmt":"2025-02-12T20:30:35","slug":"a-new-method-to-detect-organ-specific-inflammation","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/a-new-method-to-detect-organ-specific-inflammation\/","title":{"rendered":"A New Method to Detect Organ-Specific Inflammation"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Case Western Reserve University-led researchers have pioneered a method to detect organ-specific inflammation using antibodies. This breakthrough promises advancements in diagnosing diseases such as heart disease, Alzheimer&#8217;s and cancer, as well as aiding drug discovery.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers led by Case Western Reserve University have developed a novel method to detect inflammation in specific organs and tissues, potentially revolutionizing how diseases like heart disease, Alzheimer\u2019s and cancer are diagnosed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nearly all diseases have inflammation at their core. However, current blood tests fall short of pinpointing where inflammation occurs. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Now, the team has identified a way to use antibodies to detect inflammation, which may lead to the development of disease-specific biomarkers. This advancement could also fuel new drug discoveries.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis research opens up an amazing number of pathways for future studies,\u201d corresponding author Greg Tochtrop, a professor of chemistry at Case Western Reserve, said in a <a href=\"https:\/\/thedaily.case.edu\/a-new-way-to-detect-inflammation\/\" target=\"_blank\" rel=\"noopener\" title=\"\">news release<\/a>. \u201cIt will lead directly to better understanding inflammation and detecting diseases, as well as to discovering new drugs.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2415039122\" target=\"_blank\" rel=\"noopener\" title=\"\">Published<\/a> in the Proceedings of the National Academy of Sciences (PNAS), this research could mark a turning point in medical diagnostics and therapeutic development.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Detecting the Indelible Trace of Inflammation<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When the body faces inflammation, it often results in producing highly reactive oxygen species (ROS). These molecules, while crucial for defending against pathogens, can inflict severe damage on DNA, proteins and lipids. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Exposure to factors like ultraviolet light, pollution and smoking can exacerbate ROS production, leading to oxidative stress.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tochtrop and his team delved into the interaction between ROS and linoleic acid, a common fatty acid in cell membranes. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">They discovered that this interaction produced unique compounds, known as epoxyketooctadecanoic acids (EKODEs), which bind firmly to cysteine, an amino acid. These stable compounds accumulate in various tissues affected by oxidative stress, such as the brain, heart,and liver.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Using mouse models, the researchers developed antibodies to detect different types of EKODEs, successfully identifying their presence in both mouse and human tissues.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWhat makes this so interesting and so potentially valuable is that we could detect unique compounds and concentrations in different tissues and organs, which means that you could potentially detect a variety of diseases with a blood test,\u201d Tochtrop added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The envisioned test could function similarly to the A1C test for diabetes, which measures glucose-coated hemoglobin levels in the blood over a three-month period. An EKODE test could potentially reveal oxidative stress in specific organs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">On the Hunt for Disease-Specific Biomarkers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The next phase, according to Tochtrop, involves identifying specific EKODE targets in various organs to link them with particular diseases. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One area of interest includes EKODEs produced in the eye due to conditions like age-related macular degeneration or diabetic retinopathy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe had to develop many of the tools in the lab to search for them in the first place,\u201d Tochtrop added, elaborating on why these biomarkers hadn\u2019t been identified previously.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers synthesized EKODE model compounds and examined their reactions with different amino acids, discovering that cysteine consistently formed a stable bond with EKODEs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe looked at the inherent chemistry of the system, predicted what would form, and then searched for them,&#8221; added Tochtrop. &#8220;There are very important translational implications, but this is an example of how looking at things from first principles can really inform the next steps to developing clinical tests.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Implications for Drug Discovery<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Apart from diagnostic applications, this research could significantly impact drug discovery. With drug developers currently seeking reactive cysteines as drug targets, the research could unveil new reactive cysteines for therapeutic targeting.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cIdentifying reactive cysteines is central to drug discovery right now. This could help uncover many reactive cysteines that could be targeted for drug discovery, which is a valuable offshoot of our research,\u201d Tochtrop concluded.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers led by Case Western Reserve University have developed a novel method to detect inflammation in specific organs and tissues, potentially revolutionizing how diseases like heart disease, Alzheimer\u2019s and cancer are diagnosed. Nearly all diseases have inflammation at their core. However, current blood tests fall short of pinpointing where inflammation occurs. Now, the team has [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-17598","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers led by Case Western Reserve University have developed a novel method to detect inflammation in specific organs and tissues, potentially revolutionizing how diseases like heart disease, Alzheimer\u2019s and cancer are diagnosed. Nearly all diseases have inflammation at their core. However, current blood tests fall short of pinpointing where inflammation occurs. Now, the team has&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/17598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=17598"}],"version-history":[{"count":10,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/17598\/revisions"}],"predecessor-version":[{"id":18082,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/17598\/revisions\/18082"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=17598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=17598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=17598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}