{"id":15000,"date":"2025-01-13T22:21:20","date_gmt":"2025-01-13T22:21:20","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=15000"},"modified":"2025-01-13T22:38:51","modified_gmt":"2025-01-13T22:38:51","slug":"new-study-reveals-how-car-t-cells-molecular-dynamics-boost-cancer-fighting-power","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-study-reveals-how-car-t-cells-molecular-dynamics-boost-cancer-fighting-power\/","title":{"rendered":"New Study Reveals How CAR T Cells Kill Cancer"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Researchers led by Baylor College of Medicine have discovered key differences in the cancer-fighting behaviors of CAR T cells, unveiling the potential to engineer more effective treatments for challenging cancer types.<br><\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A new study <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adq8114\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in Science Advances unveils significant findings about the cancer-killing behavior of two types of chimeric antigen receptor (CAR) T cells. Scientists from Baylor College of Medicine, alongside collaborators from Texas Children\u2019s Cancer Center and other institutions,  have uncovered the distinct molecular dynamics that occur when these immune cells engage cancer cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study dives into the immune synapse, the critical zone where CAR T cells bind with their cancer targets. By exploring how molecular interactions in this zone affect antitumor activity, the researchers aim to refine CAR T cell designs for more effective cancer treatment, particularly against hard-to-treat solid tumors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe looked at two different types of CAR T cells. The first, CD28.\u03b6-CART cells, are like sprinters. They kill cancer cells quickly and efficiently, but their activity is short-lived. The second, 4-1BB.\u03b6-CART cells, are like marathon runners. They kill cancer cells consistently over a long period,\u201d senior author Nabil Ahmed, M.D., a professor of pediatrics \u2013 hematology and oncology at Baylor and Texas Children\u2019s, said in a <a href=\"https:\/\/www.bcm.edu\/news\/a-battle-of-rafts-how-molecular-dynamics-in-car-t-cells-explain-their-cancer-killing-behavior\" target=\"_blank\" rel=\"noopener\" title=\"\">news release<\/a>. \u201cWe need to understand what\u2019s happening at the molecular level so we can engineer CAR T cells to adapt their killing behavior to target hard-to-treat malignancies, such as solid tumors.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Led by Ahmed Gad, the study&#8217;s first author and postdoctoral associate in Ahmed&#8217;s lab, the team focused on isolating the membrane lipid rafts \u2014 cholesterol-rich cell surface regions where crucial molecular interactions occur \u2014 to study the dynamics of CAR T cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The findings revealed that CD28.\u03b6-CAR molecules transit swiftly through the synapse, enabling rapid, successive killing of cancer cells, whereas 4-1BB.\u03b6-CAR molecules linger and foster a more sustained, cooperative killing approach.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cObserving the distinct pattern of dynamics between single molecules helps us understand the big picture of how these products work,\u201d Gad said in the press release. \u201cNext, we are studying how to dynamically adapt these CAR T cells at the synapse level to make them more effective.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These insights pave the way for engineering CAR T cells that could adapt their behavior to combat various types of cancer, particularly solid tumors that have been notoriously challenging to treat.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cTumors are very sophisticated. We need to adapt our tools to the biology of the disease. This may involve using multiple tools that work in different ways at different stages,\u201d Ahmed added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By enhancing the understanding of CAR T cell molecular dynamics, this research holds promise for revolutionizing cancer treatment strategies, potentially offering new hope for patients facing malignancies that were previously elusive to conventional therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study published in Science Advances unveils significant findings about the cancer-killing behavior of two types of chimeric antigen receptor (CAR) T cells. Scientists from Baylor College of Medicine, alongside collaborators from Texas Children\u2019s Cancer Center and other institutions, have uncovered the distinct molecular dynamics that occur when these immune cells engage cancer cells. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-15000","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A new study published in Science Advances unveils significant findings about the cancer-killing behavior of two types of chimeric antigen receptor (CAR) T cells. Scientists from Baylor College of Medicine, alongside collaborators from Texas Children\u2019s Cancer Center and other institutions, have uncovered the distinct molecular dynamics that occur when these immune cells engage cancer cells.&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/15000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=15000"}],"version-history":[{"count":21,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/15000\/revisions"}],"predecessor-version":[{"id":15030,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/15000\/revisions\/15030"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=15000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=15000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=15000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}