{"id":14634,"date":"2025-01-13T21:23:12","date_gmt":"2025-01-13T21:23:12","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=14634"},"modified":"2025-01-13T21:23:13","modified_gmt":"2025-01-13T21:23:13","slug":"breakthrough-discovery-of-new-skeletal-tissue-to-revolutionize-regenerative-medicine","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/breakthrough-discovery-of-new-skeletal-tissue-to-revolutionize-regenerative-medicine\/","title":{"rendered":"Breakthrough Discovery of New Skeletal Tissue to Revolutionize Regenerative Medicine"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A breakthrough discovery by UC Irvine researchers of a new skeletal tissue called lipocartilage could transform regenerative medicine, offering innovative solutions for cartilage reconstruction and repair.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a significant scientific breakthrough, an international research team led by the University of California, Irvine (UCI) has uncovered a new type of skeletal tissue that promises to advance the fields of regenerative medicine and tissue engineering.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The newly identified tissue, named &#8220;lipocartilage,&#8221; is composed of fat-filled cells called &#8220;lipochondrocytes&#8221; that provide internal stability and remain constant in size, regardless of food availability. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cLipocartilage\u2019s resilience and stability provide a compliant, elastic quality that\u2019s perfect for flexible body parts such as earlobes or the tip of the nose, opening exciting possibilities in regenerative medicine and tissue engineering, particularly for facial defects or injuries,\u201d corresponding author Maksim Plikus, a UC Irvine professor of developmental and cell biology, said in a <a href=\"https:\/\/news.uci.edu\/2025\/01\/09\/uc-irvine-led-discovery-of-new-skeletal-tissue-advances-regenerative-medicine-potential\/\" target=\"_blank\" rel=\"noopener\" title=\"\">news release<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Unlike traditional cartilage, which relies on an external extracellular matrix for strength, lipocartilage stays soft and springy thanks to its unique cellular makeup, akin to bubbled packaging material. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This innovative tissue could potentially eliminate the need for painful and invasive procedures, such as harvesting cartilage from a patient&#8217;s rib for reconstructive purposes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cCurrently, cartilage reconstruction often requires harvesting tissue from the patient\u2019s rib &#8212; a painful and invasive procedure. In the future, patient-specific lipochondrocytes could be derived from stem cells, purified and used to manufacture living cartilage tailored to individual needs. With the help of 3D printing, these engineered tissues could be shaped to fit precisely, offering new solutions for treating birth defects, trauma, and various cartilage diseases,\u201d Plikus added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The discovery also sheds light on the sophisticated mechanisms behind lipocartilage&#8217;s formation and maintenance. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ads9960\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in the journal Science. revealed that lipocartilage cells create and manage their own lipid reservoirs, maintaining their size and providing essential support to the tissue. When these lipids are removed, the tissue becomes brittle, underscoring the crucial role of lipochondrocytes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lead author Raul Ramos, a postdoctoral researcher in Plikus\u2019s lab, highlighted the groundbreaking nature of the findings. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe discovery of the unique lipid biology of lipocartilage challenges long-standing assumptions in biomechanics and opens doors to countless research opportunities,\u201d he said in the news release.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Franz Leydig first identified the presence of fat droplets in the cartilage of rat ears in 1854, an observation that was largely forgotten until now. With current advanced biochemical tools and imaging methods, the researchers were able to explore lipocartilage&#8217;s molecular biology, metabolism and structural role in-depth.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The presence of lipochondrocytes in various mammals, with some like bats forming intricate shapes in their oversized ears to enhance hearing, opens pathways for further research in understanding the stability and genetic processes governing these cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cFuture directions include gaining an understanding of how lipochondrocytes maintain their stability over time and the molecular programs that govern their form and function, as well as insights into the mechanisms of cellular aging,&#8221; added Ramos. &#8220;Our findings underscore the versatility of lipids beyond metabolism and suggest new ways to harness their properties in tissue engineering and medicine.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a significant scientific breakthrough, an international research team led by the University of California, Irvine (UCI) has uncovered a new type of skeletal tissue that promises to advance the fields of regenerative medicine and tissue engineering. The newly identified tissue, named &#8220;lipocartilage,&#8221; is composed of fat-filled cells called &#8220;lipochondrocytes&#8221; that provide internal stability and [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-14634","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a significant scientific breakthrough, an international research team led by the University of California, Irvine (UCI) has uncovered a new type of skeletal tissue that promises to advance the fields of regenerative medicine and tissue engineering. The newly identified tissue, named &#8220;lipocartilage,&#8221; is composed of fat-filled cells called &#8220;lipochondrocytes&#8221; that provide internal stability and&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=14634"}],"version-history":[{"count":12,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14634\/revisions"}],"predecessor-version":[{"id":14981,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14634\/revisions\/14981"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=14634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=14634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=14634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}