{"id":14382,"date":"2025-01-08T17:51:53","date_gmt":"2025-01-08T17:51:53","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=14382"},"modified":"2025-01-08T17:51:54","modified_gmt":"2025-01-08T17:51:54","slug":"new-study-brings-alzheimers-blood-test-closer-to-reality","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-study-brings-alzheimers-blood-test-closer-to-reality\/","title":{"rendered":"New Study Brings Alzheimer\u2019s Blood Test Closer to Reality"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Researchers led by NYU Langone Health have discovered key blood biomarkers that could pave the way for early detection and better treatment of Alzheimer\u2019s disease. The study unravels sex-specific differences and offers new hope for combating this debilitating condition.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In a new study, researchers led by NYU Langone Health have made significant strides toward developing a blood test for early-stage Alzheimer\u2019s disease. The findings, <a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02862-5\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in Molecular Psychiatry, could revolutionize diagnostics and treatment strategies for this debilitating condition.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study revealed that declining blood levels of acetyl-L-carnitine and free carnitine, two naturally occurring molecules in the body, track closely with the worsening of Alzheimer\u2019s disease. The decline was particularly evident in women, with levels dropping gradually as cognitive impairment progressed from mild to severe. In men, significant declines were observed only in acetyl-L-carnitine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOur findings offer the strongest evidence to date that decreased blood levels of acetyl-L-carnitine and free carnitine could act as blood biomarkers for identifying those who have Alzheimer\u2019s disease, and potentially those who are at greater risk of developing early dementia,\u201d study lead investigator Betty Bigio, a research assistant professor in the Department of Psychiatry at NYU Grossman School of Medicine, said in a <a href=\"https:\/\/nyulangone.org\/news\/study-advances-possible-blood-test-early-stage-alzheimers-disease\" target=\"_blank\" rel=\"noopener\" title=\"\">news release<\/a>. &#8220;The results also might explain the differences by sex in Alzheimer\u2019s disease, with more women than men having dementia\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers analyzed data from 93 volunteers diagnosed with varying degrees of cognitive impairment and 32 cognitively healthy individuals. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By closely linking blood levels of acetyl-L-carnitine and free carnitine to increased amyloid beta and tangled tau protein levels &#8212; long-standing markers of Alzheimer\u2019s severity &#8212; the team achieved a diagnostic accuracy of 93% when combining traditional cerebrospinal fluid tests with blood molecule levels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cBecause declines in acetyl-L-carnitine and free carnitine tracked closely with the severity of Alzheimer\u2019s disease, the molecular pathways involved in their production offer other possible therapeutic targets for getting at the root cause of the disease and potentially intervening before permanent brain damage occurs,\u201d added senior study investigator Carla Nasca, an assistant professor in the Department of Psychiatry and the\u00a0Department of Neuroscience and Physiology\u00a0at NYU Grossman School of Medicine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Six million Americans, most of whom are over the age of 65 and predominantly women, are currently estimated to be living with some form of Alzheimer\u2019s disease. The study&#8217;s promising results have profound implications for early detection and intervention, potentially reducing the disease&#8217;s progression via non-invasive methods.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nasca emphasized the need for further research to understand the molecular pathways controlling acetyl-L-carnitine production. She noted the potential for developing a blood test to track Alzheimer\u2019s progression more easily than current methods, which involve painful and risky spinal taps.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As the team continues to explore these findings, there is hope this research could lead to more effective early interventions and therapeutic approaches, directly addressing the urgent and growing Alzheimer\u2019s crisis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a new study, researchers led by NYU Langone Health have made significant strides toward developing a blood test for early-stage Alzheimer\u2019s disease. The findings, published in Molecular Psychiatry, could revolutionize diagnostics and treatment strategies for this debilitating condition. The study revealed that declining blood levels of acetyl-L-carnitine and free carnitine, two naturally occurring molecules [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-14382","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a new study, researchers led by NYU Langone Health have made significant strides toward developing a blood test for early-stage Alzheimer\u2019s disease. The findings, published in Molecular Psychiatry, could revolutionize diagnostics and treatment strategies for this debilitating condition. The study revealed that declining blood levels of acetyl-L-carnitine and free carnitine, two naturally occurring molecules&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=14382"}],"version-history":[{"count":14,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14382\/revisions"}],"predecessor-version":[{"id":14439,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14382\/revisions\/14439"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=14382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=14382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=14382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}