{"id":14286,"date":"2025-01-07T18:04:38","date_gmt":"2025-01-07T18:04:38","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=14286"},"modified":"2025-01-07T19:54:17","modified_gmt":"2025-01-07T19:54:17","slug":"breakthrough-study-reveals-how-stress-aggravates-skin-allergies","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/breakthrough-study-reveals-how-stress-aggravates-skin-allergies\/","title":{"rendered":"Breakthrough Study Reveals How Stress Aggravates Skin Allergies"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A pioneering study from Juntendo University and Okayama University explains how stress impairs immune cell function, worsening skin allergies by preventing the clearance of dead cells. This groundbreaking research has significant implications for treating stress-related inflammatory diseases.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Psychological stress is widely known to exacerbate skin allergies, but the complex molecular mechanisms underlying this phenomenon have been elusive \u2014 until now. Researchers from Japan have made a significant discovery, shedding light on how stress interferes with immune responses, leading to deteriorating allergic symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study, <a href=\"https:\/\/www.jacionline.org\/article\/S0091-6749(24)01231-4\/fulltext\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in The Journal of Allergy and Clinical Immunology, was conducted by researchers from the Juntendo University Graduate School of Medicine and the Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Their work focuses on IgE-mediated cutaneous allergic inflammation (IgE-CAI), a model characterized by swelling and immune cell infiltration at allergy sites. The team discovered that stress reduces the ability of specialized anti-inflammatory cells, known as PD-L2-positive macrophages, to clear dead cells from the site of inflammation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis study is the first in the world to demonstrate that stress, through the sympathetic nervous system, disrupts macrophage function, which normally helps suppress allergic reactions, thereby intensifying allergic responses,\u201d co-lead author Soichiro Yoshikawa, an associate professor at the Juntendo University Graduate School of Medicine, said in a <a href=\"https:\/\/en.juntendo.ac.jp\/highlights\/news\/nid616\" target=\"_blank\" rel=\"noopener\" title=\"\">news release<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Using a mouse model of IgE-CAI, the researchers noted that psychological stress linked to decreased gene expression in macrophages responsible for dead cell clearance, a process called efferocytosis. This led to dead cell accumulation, triggering increased infiltration of eosinophils, immune cells responsible for allergic inflammation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Further analysis revealed that stress impacts the activity of the \u03b22-adrenergic receptor (Adrb2) in macrophages, impairing their function. As a result, macrophages exposed to stress exhibited reduced efferocytosis, worsening skin allergy symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOur findings suggest that the impact of psychological stress on immune cells is long-lasting and can even affect macrophages that differentiate later. This phenomenon, referred to as \u2018stress memory,\u2019 implies that severe stress leaves a lingering imprint on immune cells, influencing their function and contributing to disease development,\u201d added Yoshikawa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Moreover, the study identified that dead cell accumulation stimulates CCL24 protein expression, attracting eosinophils to the inflammation site, thereby worsening allergic responses. However, blocking caspase-1 enzyme activity reduced this effect, opening potential avenues for therapeutic interventions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cAnti-inflammatory macrophages play crucial roles in various diseases, including cancer, autoimmune disorders and wound healing. This study not only sheds light on the impact of stress on allergic inflammation but also lays the groundwork for exploring how stress exacerbates other diseases involving these macrophages,\u201d Yoshikawa added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Understanding stress-induced immune cell dysfunction offers promising prospects for novel treatments targeting stress-related inflammatory diseases. Providing insights into stress memory and its lasting effects on the immune system could pave the way for groundbreaking therapeutic strategies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Psychological stress is widely known to exacerbate skin allergies, but the complex molecular mechanisms underlying this phenomenon have been elusive \u2014 until now. Researchers from Japan have made a significant discovery, shedding light on how stress interferes with immune responses, leading to deteriorating allergic symptoms. The study, published in The Journal of Allergy and Clinical [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-14286","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Psychological stress is widely known to exacerbate skin allergies, but the complex molecular mechanisms underlying this phenomenon have been elusive \u2014 until now. Researchers from Japan have made a significant discovery, shedding light on how stress interferes with immune responses, leading to deteriorating allergic symptoms. The study, published in The Journal of Allergy and Clinical&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=14286"}],"version-history":[{"count":11,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14286\/revisions"}],"predecessor-version":[{"id":14315,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/14286\/revisions\/14315"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=14286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=14286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=14286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}