{"id":13577,"date":"2025-01-02T18:26:21","date_gmt":"2025-01-02T18:26:21","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=13577"},"modified":"2025-01-02T18:26:22","modified_gmt":"2025-01-02T18:26:22","slug":"why-ttp-plays-a-critical-role-in-controlling-allergic-inflammation","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/why-ttp-plays-a-critical-role-in-controlling-allergic-inflammation\/","title":{"rendered":"Why TTP Plays a Critical Role in Controlling Allergic Inflammation"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Researchers led by the Institute of Science Tokyo have discovered that tristetraprolin (TTP) regulates inflammatory responses in basophils, paving the way for new treatments for allergic diseases.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A new breakthrough in the understanding of allergic inflammation has been unveiled by researchers led by the Institute of Science Tokyo, spotlighting the pivotal role of a protein called tristetraprolin (TTP) in basophils.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Inflammation is a fundamental aspect of the body&#8217;s defense system, essential for combating infections and repairing tissue damage. Basophils, though constituting less than 1% of white blood cells, have emerged as significant triggers of allergic responses through the release of pro-inflammatory cytokines like IL-4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Led by Kensuke Miyake, a professor at the Institute of Science Tokyo, the team investigated TTP, an RNA-binding protein, and its influence on basophils. The study, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1323893024001229\" target=\"_blank\" rel=\"noopener\" title=\"\">published<\/a> in Allergology International, reveals that TTP is crucial for degrading mRNAs that encode inflammatory cytokines and chemokines, thus controlling basophil inflammatory responses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;In this study, we used wild-type and TTP-knockout mice to explore the role of TTP in basophils,&#8221; Miyake said in a <a href=\"https:\/\/www.eurekalert.org\/news-releases\/1069162\" target=\"_blank\" rel=\"noopener\" title=\"\">news release<\/a>. &#8220;Basophils from each strain were stimulated with antigen combined with IgE, IL-33, or lipopolysaccharide (LPS). We measured gene expression, mRNA stability, and inflammatory protein levels.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers employed advanced techniques such as RNA sequencing (RNA-seq) and SLAM-seq to analyze gene expression and mRNA stability on a transcriptome-wide scale. Using genetically engineered basophil-specific TTP-knockout mice, they further explored the real-world implications of TTP deficiency in an oxazolone-induced atopic dermatitis model.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The findings were significant. When basophils were stimulated with antigen\/IgE, IL-33 or LPS, TTP expression was notably upregulated, helping to degrade mRNAs and prevent excessive cytokine production. In the absence of TTP, mRNAs encoding critical inflammatory molecules like Il4, Il13, Areg, Ccl3, Cxcl2 and Ptgs2 remained stable for longer periods, resulting in elevated cytokine and chemokine production.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><span style=\"font-weight: 400;\">Miyake emphasized the study&#8217;s importance<\/span>, adding: <span style=\"font-weight: 400;\">&#8220;By promoting the degradation of mRNA for inflammatory molecules, TTP prevents their overproduction. In the absence of TTP, mRNA remains stable for a longer period, leading to excessive cytokine production and exacerbated allergic responses.&#8221;\u00a0<\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><span style=\"font-weight: 400;\">This research identifies TTP as a significant regulator of inflammatory responses in basophils and suggests that targeting TTP or its pathways could lead to novel treatments for allergic diseases, such as asthma and atopic dermatitis.<\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new breakthrough in the understanding of allergic inflammation has been unveiled by researchers led by the Institute of Science Tokyo, spotlighting the pivotal role of a protein called tristetraprolin (TTP) in basophils. Inflammation is a fundamental aspect of the body&#8217;s defense system, essential for combating infections and repairing tissue damage. Basophils, though constituting less [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-13577","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"A new breakthrough in the understanding of allergic inflammation has been unveiled by researchers led by the Institute of Science Tokyo, spotlighting the pivotal role of a protein called tristetraprolin (TTP) in basophils. Inflammation is a fundamental aspect of the body&#8217;s defense system, essential for combating infections and repairing tissue damage. Basophils, though constituting less&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/13577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=13577"}],"version-history":[{"count":14,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/13577\/revisions"}],"predecessor-version":[{"id":13700,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/13577\/revisions\/13700"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=13577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=13577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=13577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}