{"id":12082,"date":"2024-12-11T21:30:53","date_gmt":"2024-12-11T21:30:53","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=12082"},"modified":"2024-12-11T21:30:55","modified_gmt":"2024-12-11T21:30:55","slug":"stanford-researchers-develop-first-ever-topical-vaccine-using-skin-bacteria","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/stanford-researchers-develop-first-ever-topical-vaccine-using-skin-bacteria\/","title":{"rendered":"Stanford Researchers Develop First-Ever Topical Vaccine Using Skin Bacteria"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">Stanford University scientists have engineered a groundbreaking topical vaccine using the common skin bacterium Staphylococcus epidermidis. This promising innovation could replace traditional needle-based vaccinations with a painless cream, making immunization more accessible and less daunting.<br><\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Imagine a vaccine that you could simply rub onto your skin rather than enduring the discomfort of a needle. This groundbreaking prospect is closer to reality thanks to the innovative work of researchers at Stanford University.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Michael Fischbach, the Liu (Liao) Family Professor and a professor of bioengineering at Stanford, and his team have domesticated <em>Staphylococcus epidermidis<\/em>, a common skin bacterium, transforming it into a workable, pain-free vaccine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;We all hate needles \u2014 everybody does,&#8221; Fischbach said in a <a href=\"https:\/\/med.stanford.edu\/news\/all-news\/2024\/12\/skin-bacteria-vaccine.html\" title=\"\">news release<\/a>. &#8220;I haven\u2019t found a single person who doesn\u2019t like the idea that it\u2019s possible to replace a shot with a cream.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The human skin may not seem like an ideal environment for living organisms due to its dryness and salinity, but <em>Staphylococcus epidermidis<\/em> thrives there.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;These bugs reside on every hair follicle of virtually every person on the planet,&#8221; Fischbach added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Driven by a curiosity about the skin\u2019s ecosystem, Fischbach and postdoctoral scholar Djenet Bousbaine, a senior and lead author of the study, explored whether the immune system of mice would produce antibodies in response to <em>S. epidermidis<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Their experiments revealed that the immune system does indeed mount a robust antibody response to the bacterium.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;It\u2019s as if the mice had been vaccinated,&#8221; Fischbach added, noting the immune response was comparable to that of traditional vaccinations. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, similar high levels of antibodies were found in humans, suggesting a preemptive immune defense mechanism against skin colonizers.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The breakthrough came when the team engineered <em>S. epidermidis<\/em> to include a protein that triggers an immune response. This protein, known as Aap, was equipped with elements from toxins like tetanus, to observe if it could invoke a specific antibody response.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Djenet did some clever engineering,&#8221; Fischbach said, highlighting Bousbaine\u2019s efforts.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Their approach proved effective: mice treated with the engineered <em>S. epidermidis<\/em> developed strong antibodies against these toxins. This protected them from lethal doses, showcasing the potential of this novel vaccination method.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The implications are profound. This topical vaccine could potentially be adapted for protection against various pathogens, including viruses and fungi. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;We think this will work for viruses, bacteria, fungi and one-celled parasites,&#8221; Fischbach said, adding that this method could omit the inflammatory responses typical of current vaccines.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research, <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08489-4\" title=\"\">published<\/a> in the journal Nature, could lead to clinical trials within two to three years, according to Fischbach.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Imagine a vaccine that you could simply rub onto your skin rather than enduring the discomfort of a needle. This groundbreaking prospect is closer to reality thanks to the innovative work of researchers at Stanford University. Michael Fischbach, the Liu (Liao) Family Professor and a professor of bioengineering at Stanford, and his team have domesticated [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-12082","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Imagine a vaccine that you could simply rub onto your skin rather than enduring the discomfort of a needle. This groundbreaking prospect is closer to reality thanks to the innovative work of researchers at Stanford University. Michael Fischbach, the Liu (Liao) Family Professor and a professor of bioengineering at Stanford, and his team have domesticated&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/12082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=12082"}],"version-history":[{"count":12,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/12082\/revisions"}],"predecessor-version":[{"id":12101,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/12082\/revisions\/12101"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=12082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=12082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=12082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}