{"id":12018,"date":"2024-12-11T20:49:26","date_gmt":"2024-12-11T20:49:26","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=12018"},"modified":"2024-12-11T20:49:39","modified_gmt":"2024-12-11T20:49:39","slug":"new-compound-shows-promise-in-treating-rosacea-and-eczema-study-finds","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/new-compound-shows-promise-in-treating-rosacea-and-eczema-study-finds\/","title":{"rendered":"New Compound Shows Promise in Treating Rosacea and Eczema, Study Finds"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A University of Pittsburgh-led study identifies SYM2081 as a potential treatment for inflammatory skin conditions. The compound suppresses mast cell activity, offering new hope for conditions like rosacea and eczema.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">For those suffering from rosacea, eczema and other inflammatory skin conditions, a new treatment could be on the horizon. Researchers led by the University of Pittsburgh have discovered that a compound named SYM2081 can effectively inhibit the activity of mast cells, potentially preventing the symptoms that often plague patients. Their findings, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adq9133\" title=\"\">published<\/a> in Science Translational Medicine, highlight the promise of this new approach.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cI\u2019m really excited about the clinical possibilities of this research,\u201d senior author Daniel Kaplan, a professor of dermatology and immunology at Pitt, said in a <a href=\"https:\/\/inside.upmc.com\/feeling-itchy-study-suggests-novel-way-to-treat-inflammatory-skin-conditions\/\" title=\"\">news release<\/a>. \u201cCurrently, there aren\u2019t a lot of good therapies that target mast cells, so we think that our approach could potentially have huge benefits in many skin conditions, including rosacea, eczema, urticaria and mastocytosis.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Understanding Mast Cells<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Mast cells play a dual role in the immune system. When they are functioning correctly, they can provide protection against threats like bee stings and bacterial infections. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, when they malfunction, they can cause a host of problems, including allergic reactions, swelling and severe cases of anaphylaxis. Mast cells release histamine and other compounds during this process, known as degranulation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a previous study <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867421002877?via%3Dihub\" title=\"\">published in Cell<\/a>, Kaplan&#8217;s team found that neurons in the skin release a neurotransmitter called glutamate that can suppress mast cell activity. This revelation brought new questions to the table.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThis finding led us to wonder if doing the opposite would have a beneficial effect,\u201d Kaplan added. \u201cIf we activate the glutamate receptor, maybe we can suppress mast cell activity and inflammation.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A New Hope With SYM2081<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The recent study tackled this hypothesis by examining SYM2081, a compound also known as 4-methylglutamate that activates the GluK2 glutamate receptor, found predominantly on mast cells. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Led by Youran Zhang, a medical student at Tsinghua University who conducted this research as a visiting scholar in Kaplan\u2019s lab, and Tina Sumpter, a research assistant professor in the Department of Dermatology at Pitt, the team demonstrated that SYM2081 effectively reduced mast cell degranulation and proliferation in both mice and human skin samples.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Applying a topical cream containing SYM2081 to mice before inducing symptoms similar to rosacea and eczema significantly mitigated skin inflammation and other disease-related symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Clinical Possibilities<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">According to the researchers, these findings indicate that a daily cream containing a GluK2-activating compound could be a promising preventive treatment for rosacea and other inflammatory skin conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cAlthough there are excellent therapies available for different types of rosacea, many are antibiotic-based and they only target some of the symptoms,\u201d Kaplan added. \u201cThere are no good therapies for flushing, so this is a significant unmet need. Our study suggests that suppressing mast cells by activating GluK2 could reduce the flushing associated with rosacea.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Next Steps<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">With these promising results, the research team now aims to engineer new GluK2-activating compounds for potential clinical trials. They have already applied for a patent through the Pitt Office of Innovation and Entrepreneurship\u2019s Innovation Institute.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This pioneering research offers new hope for millions suffering from chronic skin conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The journey from groundbreaking discovery to clinical application is long, but these findings represent a significant step forward. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>For those suffering from rosacea, eczema and other inflammatory skin conditions, a new treatment could be on the horizon. Researchers led by the University of Pittsburgh have discovered that a compound named SYM2081 can effectively inhibit the activity of mast cells, potentially preventing the symptoms that often plague patients. Their findings, published in Science Translational [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-12018","post","type-post","status-publish","format-standard","hentry","category-health"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"For those suffering from rosacea, eczema and other inflammatory skin conditions, a new treatment could be on the horizon. Researchers led by the University of Pittsburgh have discovered that a compound named SYM2081 can effectively inhibit the activity of mast cells, potentially preventing the symptoms that often plague patients. Their findings, published in Science Translational&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/12018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=12018"}],"version-history":[{"count":9,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/12018\/revisions"}],"predecessor-version":[{"id":12063,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/12018\/revisions\/12063"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=12018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=12018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=12018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}