{"id":11189,"date":"2024-11-19T18:16:57","date_gmt":"2024-11-19T18:16:57","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=11189"},"modified":"2024-11-19T18:16:58","modified_gmt":"2024-11-19T18:16:58","slug":"groundbreaking-research-on-cell-density-paves-way-for-future-of-synthetic-tissues","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/groundbreaking-research-on-cell-density-paves-way-for-future-of-synthetic-tissues\/","title":{"rendered":"Groundbreaking Research on Cell Density Paves Way for Future of Synthetic Tissues"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">In a remarkable study published in <em>Nature Communications<\/em>, researchers from USC and Caltech explored the role of cell density in tissue formation. This discovery could significantly impact the future of regenerative medicine and synthetic tissue engineering.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-0dfbf163 wp-block-group-is-layout-flex\"><div style=\"font-size:16px;\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p>In a ground-breaking study <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-53078-8\" title=\"\">published<\/a> in Nature Communications, scientists from USC Stem Cell and Caltech have revealed crucial insights into how cell density influences the formation of multicellular structures, potentially paving the way for advancements in synthetic tissue engineering and regenerative medicine.<\/p>\n\n\n\n<p>\u201cThis paper represents progress towards our big picture goal of engineering synthetic tissues,\u201d Leonardo Morsut, an assistant professor of stem cell biology and regenerative medicine at the Keck School of Medicine of USC who holds a joint appointment with the Biomedical Engineering department at the USC Viterbi School of Engineering, said in a <a href=\"https:\/\/stemcell.keck.usc.edu\/exerting-crowd-control\/\" title=\"\">news release<\/a>. \u201cSynthetic tissues could have endless medical applications, ranging from testing potential drugs or therapies to providing grafts or transplants for patients.\u201d<\/p>\n\n\n\n<p>The collaborative research, led by Morsut and Matthew Thomson, an assistant professor of computational biology at Caltech, focused on the impacts of cell density \u2014 essentially how tightly cells are packed in a given space \u2014 on tissue formation. Their efforts combined computational models with laboratory experiments to manipulate how mouse cells self-organize into complex structures.<\/p>\n\n\n\n<p>Using two types of engineered mouse cells, connective tissue cells and stem cells, the team employed a synthetic cellular communication system known as \u201csynNotch\u201d to control this development. SynNotch, a protein engineered into cells, acts as a sensor that activates specific genes in response to external signals. <\/p>\n\n\n\n<p>In these experiments, the activation system included green fluorescence, making it simpler to observe and manipulate cellular patterns.<\/p>\n\n\n\n<p>An unexpected observation during the experiments revealed that cell density played a more crucial role than initially thought. <\/p>\n\n\n\n<p>\u201cWe would see different outcomes of the patterning when we would start with genetically identical cells in different numbers,\u201d added Morsut. <\/p>\n\n\n\n<p>This variability led to the discovery that above certain densities, synNotch had diminished effects, and cells did not form expected patterns. This challenge was further complicated by the dynamic nature of cell proliferation, which continually altered the cell density.<\/p>\n\n\n\n<p>Co-first author Pranav S. Bhamidipati took this puzzle to the computational realm, creating a model to predict and clarify the complex interactions at play. <\/p>\n\n\n\n<p>&#8220;For me, this was one of the first times in my life where computational modeling has been able to predict behaviors that look like what actually happens in the cells,\u201d Thomson said in the news release.<\/p>\n\n\n\n<p>Guided by these predictive models, the researchers were able to manipulate cell density to generate specific, predictable fluorescent patterns over time. <\/p>\n\n\n\n<p>The breakthrough came when co-first author Josquin Courte discovered that greater cell density leads to stress, which accelerates the breakdown of cell surface sensors like synNotch, thus demonstrating that cell density can broadly guide cellular construction.<\/p>\n\n\n\n<p>\u201cNature has relied on cell density in conjunction with genetic circuits to generate the remarkable diversity of multicellular structures, tissues, and organs,\u201d Morsut added. \u201cNow we can co-opt this same strategy to advance our efforts to build synthetic multicellular structures \u2014 and eventually tissues and organs\u2014for regenerative medicine.\u201d<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>This cutting-edge research highlights the importance of cell density in tissue engineering, marking a pivotal advancement that brings science one step closer to revolutionizing medical treatments through synthetic tissues.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a ground-breaking study published in Nature Communications, scientists from USC Stem Cell and Caltech have revealed crucial insights into how cell density influences the formation of multicellular structures, potentially paving the way for advancements in synthetic tissue engineering and regenerative medicine. \u201cThis paper represents progress towards our big picture goal of engineering synthetic tissues,\u201d [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-11189","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"In a ground-breaking study published in Nature Communications, scientists from USC Stem Cell and Caltech have revealed crucial insights into how cell density influences the formation of multicellular structures, potentially paving the way for advancements in synthetic tissue engineering and regenerative medicine. \u201cThis paper represents progress towards our big picture goal of engineering synthetic tissues,\u201d&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/11189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=11189"}],"version-history":[{"count":4,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/11189\/revisions"}],"predecessor-version":[{"id":11301,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/11189\/revisions\/11301"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=11189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=11189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=11189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}