{"id":11027,"date":"2024-11-18T17:16:45","date_gmt":"2024-11-18T17:16:45","guid":{"rendered":"https:\/\/www.tun.com\/home\/?p=11027"},"modified":"2025-02-21T19:52:11","modified_gmt":"2025-02-21T19:52:11","slug":"uc-davis-study-reveals-how-salmonella-evades-gut-defenses-to-cause-infections","status":"publish","type":"post","link":"https:\/\/www.tun.com\/home\/uc-davis-study-reveals-how-salmonella-evades-gut-defenses-to-cause-infections\/","title":{"rendered":"UC Davis Study Reveals How Salmonella Evades Gut Defenses to Cause Infections"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-uagb-blockquote uagb-block-e7eb3fc3 uagb-blockquote__skin-border uagb-blockquote__stack-img-none\"><blockquote class=\"uagb-blockquote\"><div class=\"uagb-blockquote__content\">A new UC Davis Health study uncovers how Salmonella bacteria manipulate gut nutrients to circumvent natural defenses, offering new insights for tackling gut infections.<\/div><footer><div class=\"uagb-blockquote__author-wrap uagb-blockquote__author-at-left\"><\/div><\/footer><\/blockquote><\/div>\n\n\n\n<div class=\"wp-block-group is-content-justification-space-between is-nowrap is-layout-flex wp-container-core-group-is-layout-b0ffac9c wp-block-group-is-layout-flex\"><div style=\"font-size:16px\" class=\"has-text-align-left wp-block-post-author\"><div class=\"wp-block-post-author__content\"><p class=\"wp-block-post-author__name\">The University Network<\/p><\/div><\/div>\n\n\n<div class=\"wp-block-uagb-social-share uagb-social-share__outer-wrap uagb-social-share__layout-horizontal uagb-block-ee584a31\">\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-ec619ce7\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.facebook.com\/sharer.php?u=\" tabindex=\"0\" role=\"button\" aria-label=\"facebook\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.8 90.69 226.4 209.3 245V327.7h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.3 482.4 504 379.8 504 256z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-32d99934\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/twitter.com\/share?url=\" tabindex=\"0\" role=\"button\" aria-label=\"twitter\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><path d=\"M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n\n\n\n<div class=\"wp-block-uagb-social-share-child uagb-ss-repeater uagb-ss__wrapper uagb-block-1d136f14\"><span class=\"uagb-ss__link\" data-href=\"https:\/\/www.linkedin.com\/shareArticle?url=\" tabindex=\"0\" role=\"button\" aria-label=\"linkedin\"><span class=\"uagb-ss__source-wrap\"><span class=\"uagb-ss__source-icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg><\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers at UC Davis Health have unveiled a clever mechanism that Salmonella bacteria use to overcome the gut&#8217;s natural defenses and cause infections. The study, <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2417232121\">published<\/a> in the Proceedings of the National Academy of Sciences, sheds light on how this common foodborne pathogen manipulates its environment to survive and replicate in the intestines.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;We knew that Salmonella invades the small intestine, although it is not its primary site of replication. The colon is,&#8221; lead author Andreas B\u00e4umler, a distinguished professor and vice chair of research in the Department of Medical Microbiology and Immunology at UC Davis, said in a <a href=\"https:\/\/health.ucdavis.edu\/news\/headlines\/new-study-shows-how-salmonella-tricks-gut-defenses-to-cause-infection\/2024\/11\" title=\"\">news release<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Typically, the digestive system houses trillions of beneficial bacteria that produce short-chain fatty acids (SCFAs), which fight harmful pathogens. Despite these protective compounds, Salmonella manages to thrive. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The UC Davis team asked, &#8220;How does Salmonella get around this defense?&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The answer lies in how Salmonella alters the gut&#8217;s nutrient balance. Upon entering the small intestine, the bacteria cause inflammation in the gut lining, disrupting normal amino acid absorption from food and creating an imbalance of nutrients. This shift enables Salmonella to thrive in the colon, an environment typically controlled by beneficial bacteria.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Using a mouse model, the researchers traced amino acid absorption in both the small and large intestines during infection. They found that two amino acids, lysine and ornithine, became more abundant in the gut, aiding Salmonella by counteracting SCFAs&#8217; growth-inhibiting effects. The increased presence of these amino acids allowed Salmonella to restore its acidity (pH) balance and evade the defenses of the gut microbiota.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Our findings show that Salmonella has a clever way of changing the gut\u2019s nutrient environment to its advantage. By making it harder for the body to absorb amino acids in the ileum, Salmonella creates a more favorable environment for itself in the large intestine,&#8221; B\u00e4umler added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Moreover, the study revealed that Salmonella employs its virulence factors to activate enzymes that break down key amino acids like lysine, aiding its survival and replication in the gut.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The implications of this discovery extend beyond combatting Salmonella infections. The insights gained could inform better treatments for inflammatory bowel disorders, such as Crohn&#8217;s disease and ulcerative colitis, by protecting the gut microbiota and preventing infections.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;This research uses a more holistic approach to studying gut health. It not only gives us a better understanding of how Salmonella works, but also highlights the importance of maintaining a healthy gut microbiota,&#8221; first author Lauren Radlinski, a postdoctoral fellow in the B\u00e4umler Lab, said in the news release. &#8220;Our findings could lead to new treatments that help support the microbiota during infection.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Future treatments inspired by this study might include probiotics or dietary plans aimed at bolstering the body&#8217;s natural defenses against pathogens.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;By learning how a pathogen manipulates the host\u2019s system, we can uncover ways to boost the host\u2019s natural defenses,&#8221; Radlinski added.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at UC Davis Health have unveiled a clever mechanism that Salmonella bacteria use to overcome the gut&#8217;s natural defenses and cause infections. The study, published in the Proceedings of the National Academy of Sciences, sheds light on how this common foodborne pathogen manipulates its environment to survive and replicate in the intestines. &#8220;We knew [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-no-separators","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-11027","post","type-post","status-publish","format-standard","hentry","category-science"],"acf":[],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"The University Network","author_link":"https:\/\/www.tun.com\/home\/author\/funky_junkie\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers at UC Davis Health have unveiled a clever mechanism that Salmonella bacteria use to overcome the gut&#8217;s natural defenses and cause infections. The study, published in the Proceedings of the National Academy of Sciences, sheds light on how this common foodborne pathogen manipulates its environment to survive and replicate in the intestines. &#8220;We knew&hellip;","_links":{"self":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/11027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/comments?post=11027"}],"version-history":[{"count":9,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/11027\/revisions"}],"predecessor-version":[{"id":11080,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/posts\/11027\/revisions\/11080"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/media?parent=11027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/categories?post=11027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/home\/wp-json\/wp\/v2\/tags?post=11027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}