{"id":22054,"date":"2017-09-25T16:26:07","date_gmt":"2017-09-25T20:26:07","guid":{"rendered":"https:\/\/www.tun.com\/blog\/?p=22054"},"modified":"2021-05-21T12:05:30","modified_gmt":"2021-05-21T16:05:30","slug":"nanokicking-technology-bone-growth-development","status":"publish","type":"post","link":"https:\/\/www.tun.com\/blog\/nanokicking-technology-bone-growth-development\/","title":{"rendered":"Universities of Glasgow, Stratchclyde, West of Scotland and Galway Researchers Grow Bone with \u2018Nanokicking\u2019 Technology"},"content":{"rendered":"

Researchers from the Universities of Glasgow, Stratchclyde, West of Scotland and Galway are using \u2018nanokicking\u2019 technology to <\/span>grow three-dimensional mineralized bone samples<\/span><\/a> in their laboratory. Broken, sprained, or otherwise damaged sections of bone have long presented challenges for doctors, so this technology is poised to transform the lives of many patients worldwide.<\/span><\/p>\n

The study is published in <\/span>Nature Biomedical Engineering<\/span><\/a>.<\/span><\/p>\n

The research was funded by <\/span>Engineering and Physical Sciences Research Council<\/span><\/a> (EPSRC), <\/span>Biotechnology and Biological Sciences Research Council<\/span><\/a> (BBSRC), and Sir Bobby Charlton\u2019s landmine charity <\/span>Find a Better Way<\/span><\/a>, which helps victims of landmines.<\/span><\/p>\n

Nanokicking was originally engineered for work in the area of gravitation wave detection. But the researchers were able to use the technology to turn mesenchymal stem cells, which are naturally produced by human bodies in bone marrow, into 3D bone cells. The mesenchymal stem cells are taken from human donors, placed inside collagen gels, and subjected to nanokicking, or ultra-precise, nanoscale vibrations. These cells are then converted into a \u201cbone putty\u201d that could be used to repair or replace damaged bone. Basically, the researchers are using nanokicking technology to unlock the potential in our cells to turn into other tissue, such as bone, cartilage, and muscle. <\/span><\/p>\n

\"\"<\/p>\n

\u201cHaving spent 15 years working in astrophysics and gravitational wave detection with the Laser Interferometer Gravitational-Wave Observatory (LIGO), it is amazing to see technology arising that could revolutionise key aspects of tissue engineering and regenerative medicine.\u201d <\/span>Stuart Reid<\/span><\/a>, professor of biomedical engineering at the University of Strathclyde, and formerly at the University of the West of Scotland, said <\/span>in a statement<\/span><\/a>. <\/span><\/p>\n

This advancement in bone transplant technology will make a big difference in orthopedic treatments. Of all living tissues, bone is the second most transplanted tissue in the world, second only to blood. Up until now, however, bone transplant have been limited by two factors. First, the amount of living bone that can be harvested from a patient is limited. Second, a human body is likely to reject bone harvested from other donors. <\/span><\/p>\n

The likelihood of rejection is, however, reduced by the new technology that allows for the use of a patient\u2019s own mesenchymal stem cells to generate bone. The ability to grow bone, when combined with the team\u2019s novel <\/span>printed scaffolds<\/span><\/a>, also means that it would be possible to repair larger gaps in bone.<\/span><\/p>\n

The researchers have recently used their technology to <\/span>save a dog\u2019s leg<\/span><\/a>. <\/span>\u201cIn partnership with Find A Better Way, we have already proven the effectiveness of our scaffolds in veterinary medicine, by helping to grow new bone to save the leg of a dog who would otherwise have had to have it amputated,\u201d Matthew Dalby, professor of cell engineering at the University of Glasgow and one of the lead authors of the paper, said in a statement.<\/span><\/p>\n

If further trials continue to progress in this way, we may be seeing human trials in just a few short years. <\/span><\/p>\n

\u201cWe are aiming for the First-in-Man [transplant] in 2020,\u201d <\/span>Monica P Tsimbour<\/span><\/a>i, research fellow at University of Glasgow\u2019s Institute of Molecular Cell and Systems Biology, told The University Network (TUN). <\/span><\/p>\n

Tsimbouri explained that while human bone transplant \u201cwill involve the start of clinical trials initially for small defects,\u201d the team will further develop its printed scaffold to make repairs of larger gaps in bone possible. \u201cThe technology is expected to move to a larger scale i.e., generation of scaffold implants for larger gap defects,\u201d she told TUN.<\/span><\/p>\n

The team\u2019s goal is to help victims of landmines. \u201cThat is our driving aim,\u201d Tsimbouri said. \u201cWe are privileged to be funded by major funding bodies such as EPSRC and BBSRC. We particularly thank Sir Bobby Charlton\u2019s charity Find A Better Way that aims to help civilian survivors of landmine blast injuries.\u201d<\/span><\/p>\n

Manuel Salmeron-Sanchez<\/span><\/a>, professor of bioengineering and leader of Find A Better Way project at the University of Glasgow, looks forward to to a future where victims of landmines will benefit from the technology.<\/span><\/p>\n

\u201cFor many people who have lost legs in landmine accidents, the difference between being confined to a wheelchair and being able to use a prosthesis could be only a few centimetres of bone,\u201d Salmeron-Sanchez said in a statement. <\/span><\/p>\n

The research team includes Peter G. Childs, Gabriel D. Pemberton, Jingli Yang, Vineetha Jayawarna, Wich Orapiriyakul, Karl Burgess, Cristina Gonz\u00e1lez-Garc\u00eda, Gavin Blackburn, Dilip Thomas, Catalina Vallejo-Giraldo, Manus J.P. Biggs, and Adam S.G. Curtis.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers from the Universities of Glasgow, Stratchclyde, West of Scotland and Galway are using \u2018nanokicking\u2019 technology to grow three-dimensional mineralized bone samples in their laboratory. Broken, sprained, or otherwise damaged sections of bone have long presented challenges for doctors, so this technology is poised to transform the lives of many patients worldwide. The study is […]<\/p>\n","protected":false},"author":35,"featured_media":22044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[231,232,241,230,229,243],"tags":[],"class_list":["post-22054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news","category-technology","category-medical-breakthrough","category-news","category-lead-stories","category-health"],"aioseo_notices":[],"uagb_featured_image_src":{"full":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter.png",830,533,false],"thumbnail":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter-224x144.png",224,144,true],"medium":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter-300x193.png",300,193,true],"medium_large":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter.png",830,533,false],"large":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter.png",830,533,false],"1536x1536":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter.png",830,533,false],"2048x2048":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter.png",830,533,false]},"uagb_author_info":{"display_name":"Samuel O'Brient","author_link":"https:\/\/www.tun.com\/blog\/author\/samuel\/"},"uagb_comment_info":0,"uagb_excerpt":"Researchers from the Universities of Glasgow, Stratchclyde, West of Scotland and Galway are using \u2018nanokicking\u2019 technology to grow three-dimensional mineralized bone samples in their laboratory. Broken, sprained, or otherwise damaged sections of bone have long presented challenges for doctors, so this technology is poised to transform the lives of many patients worldwide. The study is…","featured_media_src_url":"https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/09\/nanokick-bioreacter.png","_links":{"self":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/posts\/22054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/users\/35"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/comments?post=22054"}],"version-history":[{"count":0,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/posts\/22054\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/media\/22044"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/media?parent=22054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/categories?post=22054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/tags?post=22054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}