{"id":21604,"date":"2017-08-14T09:45:28","date_gmt":"2017-08-14T13:45:28","guid":{"rendered":"https:\/\/www.tun.com\/blog\/?p=21604"},"modified":"2021-05-21T10:04:52","modified_gmt":"2021-05-21T14:04:52","slug":"ohio-state-university-reprogram-cells-repair-regenerate","status":"publish","type":"post","link":"https:\/\/www.tun.com\/blog\/ohio-state-university-reprogram-cells-repair-regenerate\/","title":{"rendered":"Ohio State University Researchers Develop Technology That Could Help Reprogram Cells to Repair and Regenerate as Needed"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">A team of researchers at the Ohio State University (OSU) Wexner Medical Center and OSU\u2019s College of Engineering has <\/span><a href=\"https:\/\/wexnermedical.osu.edu\/mediaroom\/pressreleaselisting\/researchers-develop-regenerative-medicine-breakthrough\"><span style=\"font-weight: 400;\">developed<\/span><\/a><span style=\"font-weight: 400;\"> Tissue Nanotransfection (TNT), a new technology capable of generating cells needed to repair and restore tissue in patient\u2019s organs, blood vessels, and nerve cells. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">The study was recently published in the journal <\/span><a href=\"http:\/\/www.nature.com\/nnano\/journal\/vaop\/ncurrent\/full\/nnano.2017.134.html\"><span style=\"font-weight: 400;\">Nature Nanotechnology<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">The director of OSU\u2019s Center for Regenerative Medicine &amp; Cell Based Therapies <\/span><a href=\"http:\/\/www.chandansen.org\/index.html\"><span style=\"font-weight: 400;\">Chandan Sen<\/span><\/a><span style=\"font-weight: 400;\"> co-led this study with<\/span><a href=\"https:\/\/cbe.osu.edu\/people\/lee.31\"><span style=\"font-weight: 400;\"> L. James Lee<\/span><\/a><span style=\"font-weight: 400;\">, professor of chemical and biomolecular engineering at OSU\u2019s College of Engineering. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cBy using our novel nanochip technology, injured or compromised organs can be replaced,\u201d Sen said in a statement. \u201cWe have shown that skin is a fertile land where we can grow the elements of any organ that is declining.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prior attempts to regenerate cells have involved reprogramming cells in a lab and then introducing those cells to the body in need. This team of researchers set out to find a more effective and less invasive approach to cell regeneration. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">In an interview with The University Network (TUN), Sen explained his team\u2019s initiative. The researchers wanted to find a way to \u201creprogram the tissue within the body and let the conversion happen in the actual environment of the body with the interplay of other cells such as those of the immune system,\u201d he said. <\/span><\/p>\n<h2><b>How it Works<\/b><\/h2>\n<p><iframe title=\"Breakthrough device heals organs with a single touch\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/tMQ51Kj2tS0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">The small square chip is simply placed on the wounded area of the body and is zapped with a small electrical current. The current then delivers the cargo needed to change skin cells into nearly any type of cell a patient may need to heal their injury or sickness. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThis is difficult to imagine, but it is achievable, successfully working about 98 percent of the time,\u201d Sen said in a statement. \u201cWith this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you&#8217;re off. The chip does not stay with you, and the reprogramming of the cell starts.\u201d<\/span><\/p>\n<h2><b>Proven Applications <\/b><\/h2>\n<p><span style=\"font-weight: 400;\">TNT has not yet been tested on humans, but it has proven to be very effective on mice and pigs. Researchers took a mouse with little blood flow to its injured leg, applied the nanochip technology, and saw full recovery to the mouse&#8217;s leg within two weeks. <\/span><\/p>\n<h2><b>What\u2019s Next?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The technology is not limited to generating solely skin cells. The team sees many possible future implications of TNT technology. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThe technology, in some cases, will be a stand-alone solution for point of care application to patients,\u201d Sen told TUN. \u201cIn other cases, it may help generate cells of interest for other conventional applications such as tissue engineering.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As a method of tissue engineering, researchers are developing a way to use this technology to grow brain cells on the human skin. They could then take those cells and inject them into the brain to treat diseases, such as alzheimer&#8217;s or Parkinson&#8217;s disease. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">The researchers intend to start clinical trials on humans next year, but first must develop a device that would meet the criteria for human testing. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sen also informed TUN that \u201cthe technology will need the right industry partner to generate health impact.\u201d <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of researchers at the Ohio State University (OSU) Wexner Medical Center and OSU\u2019s College of Engineering has developed Tissue Nanotransfection (TNT), a new technology capable of generating cells needed to repair and restore tissue in patient\u2019s organs, blood vessels, and nerve cells. The study was recently published in the journal Nature Nanotechnology. The [&hellip;]<\/p>\n","protected":false},"author":32,"featured_media":21612,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[231,232,241,388,389,390,391,392,230,229],"tags":[],"class_list":["post-21604","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news","category-technology","category-medical-breakthrough","category-ohio-state-university-lima-campus","category-ohio-state-university-main-campus","category-ohio-state-university-mansfield-campus","category-ohio-state-university-marion-campus","category-ohio-state-university-newark-campus","category-news","category-lead-stories"],"aioseo_notices":[],"uagb_featured_image_src":{"full":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech.png",830,533,false],"thumbnail":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech-224x144.png",224,144,true],"medium":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech-300x193.png",300,193,true],"medium_large":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech.png",830,533,false],"large":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech.png",830,533,false],"1536x1536":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech.png",830,533,false],"2048x2048":["https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech.png",830,533,false]},"uagb_author_info":{"display_name":"Jackson Schroeder","author_link":"https:\/\/www.tun.com\/blog\/author\/jackson-schroeder\/"},"uagb_comment_info":0,"uagb_excerpt":"A team of researchers at the Ohio State University (OSU) Wexner Medical Center and OSU\u2019s College of Engineering has developed Tissue Nanotransfection (TNT), a new technology capable of generating cells needed to repair and restore tissue in patient\u2019s organs, blood vessels, and nerve cells. The study was recently published in the journal Nature Nanotechnology. The&hellip;","featured_media_src_url":"https:\/\/www.tun.com\/blog\/wp-content\/uploads\/2017\/08\/OhioStateTech.png","_links":{"self":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/posts\/21604","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/comments?post=21604"}],"version-history":[{"count":0,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/posts\/21604\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/media\/21612"}],"wp:attachment":[{"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/media?parent=21604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/categories?post=21604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tun.com\/blog\/wp-json\/wp\/v2\/tags?post=21604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}